{"id":2065,"date":"2023-12-12T10:31:09","date_gmt":"2023-12-12T02:31:09","guid":{"rendered":"https:\/\/unionmedin.com\/?p=2065"},"modified":"2023-12-12T10:33:19","modified_gmt":"2023-12-12T02:33:19","slug":"%e7%bf%b0%e6%a3%ae%e5%88%b6%e8%8d%afglp-1r-gipr%e5%8f%8c%e9%9d%b6%e7%82%b9%e6%bf%80%e5%8a%a8%e5%89%82i%e6%9c%9f%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e6%95%b0%e6%8d%ae%e5%9c%a8%e5%9b%bd%e9%99%85","status":"publish","type":"post","link":"https:\/\/unionmedin.com\/?p=2065","title":{"rendered":"\u7ff0\u68ee\u5236\u836fGLP-1R\/GIPR\u53cc\u9776\u70b9\u6fc0\u52a8\u5242I\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u5728\u56fd\u9645\u7cd6\u5c3f\u75c5\u8054\u76df\u5927\u4f1a\u53d1\u5e03"},"content":{"rendered":"
\n

\u7cbe\u5f69\u5185\u5bb9<\/span><\/p>\n<\/p>\n

12\u67084\u65e5\u81f37\u65e5\uff0c2023\u5e74\u56fd\u9645\u7cd6\u5c3f\u75c5\u8054\u76df\uff08IDF\uff09\u5927\u4f1a\u5728\u7ebf\u4e3e\u884c\uff0c\u7ff0\u68ee\u5236\u836fHS-20094\uff08GLP-1R\/GIPR\u53cc\u9776\u70b9\u6fc0\u52a8\u5242\uff09I\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u4ee5\u58c1\u62a5\u548c\u53e3\u5934\u6c47\u62a5\u5f62\u5f0f\u5728\u5927\u4f1a\u53d1\u5e03\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cHS-20094\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u7279\u5f81\uff0c\u5e76\u5c55\u73b0\u51fa\u663e\u8457\u964d\u7cd6\u51cf\u91cd\u7684\u4fe1\u53f7\u3002<\/p>\n<\/p>\n

\u7814\u7a76\u4ecb\u7ecd<\/span><\/p>\n<\/p>\n

\u3010\u62a5\u544a\u6807\u9898\u3011\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4ef7HS-20094\u5355\u6b21\u548c\u591a\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u52a8\u529b\u5b66\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/p>\n<\/p>\n

\u3010\u6458\u8981\u7f16\u53f7\u3011IDF23-0254<\/p>\n<\/p>\n

\u3010\u7814\u7a76\u65b9\u6cd5\u3011\u672c\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5242\u91cf\u9012\u589e\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7814\u7a76\u5206\u4e3a\u4e24\u4e2a\u9636\u6bb5\uff0c\u5355\u6b21\u7ed9\u836f\uff08SAD\uff1a0.5~10mg\uff09\u9636\u6bb5\u548c\u591a\u6b21\u7ed9\u836f\uff08MAD\uff1a1.5~15mg\uff09\u9636\u6bb5\u3002<\/p>\n<\/p>\n

\u3010\u7814\u7a76\u7ed3\u679c\u3011<\/p>\n<\/p>\n

\u5b89\u5168\u6027\u65b9\u9762\uff1aHS-20094\u603b\u4f53\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff1b\u6700\u5e38\u62a5\u544a\u7684\u6cbb\u7597\u671f\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u98df\u6b32\u51cf\u9000\u548c\u6076\u5fc3\uff0c\u4f46\u5747\u4e3a\u8f7b\u5ea6-\u4e2d\u5ea6\uff0c\u4e14\u672a\u89c1\u5242\u91cf\u4f9d\u8d56\u6027\u80c3\u80a0\u9053\u4e0d\u826f\u4e8b\u4ef6\u7684\u589e\u52a0\u3002<\/p>\n<\/p>\n

\u836f\u4ee3\u52a8\u529b\u5b66\u65b9\u9762\uff1a\u5355\u6b21\u76ae\u4e0b\u6ce8\u5c04HS-20094 0.5-10mg\u540e\uff0c\u4e2d\u4f4d\u8fbe\u5cf0\u65f6\u95f4\u4e3a8-48h\uff0c\u5e73\u5747\u534a\u8870\u671f\u4e3a160-166h\uff1b\u8fde\u7eed4\u6b21\u76ae\u4e0b\u6ce8\u5c041.5-15mg\u540e\uff0c\u5e73\u5747\u534a\u8870\u671ft1\/2\u4e3a155.6-169.8h\u3002<\/p>\n<\/p>\n

\u836f\u6548\u52a8\u529b\u5b66\u65b9\u9762\uff1a\u5728MAD\u9636\u6bb5\uff0c\u53d7\u8bd5\u8005\u63a5\u53d7\u6bcf\u5468\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u8fde\u7eed\u56db\u6b21\u540e\uff0cHS-20094\u7ec4\u7684D22 OGTT\u8840\u7cd6-\u65f6\u95f4\u66f2\u7ebf\u4e0b\u9762\u79ef\u5c0f\u4e8e\u5b89\u6170\u5242\u7ec4\uff0c\u80f0\u5c9b\u7d20-\u65f6\u95f4\u66f2\u7ebf\u4e0b\u9762\u79ef\u4e24\u7ec4\u65e0\u660e\u663e\u5dee\u5f02\uff1bHS-20094\u7ec4\u53d7\u8bd5\u8005\u7684\u4f53\u91cd\u5747\u51fa\u73b0\u8f83\u57fa\u7ebf\u4e0b\u964d\uff0c\u4e14\u5728D29\u8fbe\u5230\u8f83\u57fa\u7ebf\u4e0b\u964d\u7684\u6700\u5927\u5e45\u5ea6\uff0c\u5404\u5242\u91cf\u7ec4\u4e0b\u964d\u5e45\u5ea6\u57282.29~4.74kg\u8303\u56f4\uff0c\u800c\u5b89\u6170\u5242\u7ec4D29\u4f53\u91cd\u8f83\u57fa\u7ebf\u589e\u52a00.45kg\u3002<\/p>\n<\/p>\n

\u636eIDF\u62a5\u544a\uff0c\u9884\u8ba12030\u5e74\uff0c\u5168\u7403\u7ea6\u67096.43\u4ebf\u6210\u5e74\u4eba\uff0820-79\u5c81\uff09\u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c2045\u5e74\u8be5\u6570\u5b57\u5c06\u4e0a\u5347\u52307.83\u4ebf\u3002\u5728\u6b64\u671f\u95f4\uff0c\u4e16\u754c\u4eba\u53e3\u4f30\u8ba1\u589e\u957f20%\uff0c\u800c\u7cd6\u5c3f\u75c5\u60a3\u8005\u4eba\u6570\u4f30\u8ba1\u589e\u52a046%[1]\u3002\u6211\u56fd2\u578b\u7cd6\u5c3f\u75c5\u7684\u60a3\u75c5\u7387\u540c\u6837\u5177\u6709\u9010\u5e74\u5347\u9ad8\u8d8b\u52bf\uff0c2015\u5e74\u81f32017\u5e74\u6211\u56fd\u7cd6\u5c3f\u75c5\u60a3\u75c5\u7387\u5df2\u8fbe11.2%\uff0c\u5176\u4e2d2\u578b\u7cd6\u5c3f\u75c5\u536090%\u4ee5\u4e0a[2]\uff0c\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002<\/p>\n<\/p>\n

\u80f0\u9ad8\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff08GLP-1Rs\uff09\u662f\u4e00\u79cd\u65b0\u578b\u964d\u7cd6\u836f\uff0c\u901a\u8fc7\u6fc0\u6d3bGLP-1\u53d7\u4f53\uff0c\u4ee5\u8461\u8404\u7cd6\u6d53\u5ea6\u4f9d\u8d56\u7684\u65b9\u5f0f\u589e\u5f3a\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u6291\u5236\u80f0\u9ad8\u7cd6\u7d20\u5206\u6ccc\uff0c\u5e76\u80fd\u591f\u5ef6\u7f13\u80c3\u6392\u7a7a\uff0c\u901a\u8fc7\u4e2d\u67a2\u6027\u7684\u98df\u6b32\u6291\u5236\u51cf\u5c11\u8fdb\u98df\u91cf\uff0c\u4ece\u800c\u8fbe\u5230\u964d\u4f4e\u8840\u7cd6\u4f5c\u7528\u3002\u8fd9\u7c7b\u836f\u7269\u9664\u4e86\u5177\u6709\u660e\u786e\u7684\u964d\u7cd6\u4f5c\u7528\u4ee5\u5916\uff0c\u8fd8\u5177\u6709\u51cf\u8f7b\u4f53\u91cd\u3001\u964d\u4f4e\u8840\u538b\u3001\u4fdd\u62a4\u5fc3\u8840\u7ba1\u548c\u80be\u810f\u7b49\u4f5c\u7528[3,4]\u3002<\/p>\n<\/p>\n

HS-20094\u662f\u7ff0\u68ee\u5236\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\uff08GLP-1\uff09\u548c\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u4fc3\u80f0\u5c9b\u7d20\u591a\u80bd\uff08GIP\uff09\u53d7\u4f53\u53cc\u91cd\u6fc0\u52a8\u5242\uff0c\u901a\u8fc7\u9009\u62e9\u6027\u6fc0\u6d3bGLP-1\u53d7\u4f53\u548cGIP\u53d7\u4f53\uff0c\u6fc0\u52a8\u4e0b\u6e38\u901a\u8def\uff0c\u4ea7\u751f\u63a7\u7cd6\u3001\u51cf\u91cd\u7b49\u751f\u7269\u5b66\u6548\u5e94\uff0c\u5176\u7ed9\u836f\u65b9\u5f0f\u4e3a\u6bcf\u5468\u4e00\u6b21\uff0c\u76ae\u4e0b\u6ce8\u5c04\u3002<\/p>\n<\/p>\n

\u636e\u6089\uff0c\u7cd6\u5c3f\u75c5\u662f\u7ff0\u68ee\u5236\u836f\u91cd\u70b9\u5e03\u5c40\u7684\u75be\u75c5\u9886\u57df\u4e4b\u4e00\uff0c\u9996\u4e2a\u4e2d\u56fd\u539f\u7814\u957f\u6548GLP-1\u7c7b\u964d\u7cd6\u836f\u7269\u805a\u4e59\u4e8c\u9187\u6d1b\u585e\u90a3\u80bd\u6ce8\u5c04\u6db2\u5373\u662f\u5176\u9996\u6b3e\u7528\u4e8e2\u578b\u7cd6\u5c3f\u75c5\u7684\u521b\u65b0\u836f\uff0c\u4e5f\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u6b3ePEG\u5316\u957f\u6548\u964d\u7cd6\u836f\u7269\u3002\u76ee\u524d\uff0c\u7ff0\u68ee\u5236\u836f\u5df2\u5728\u56fd\u5185\u542f\u52a8\u5e76\u52a0\u901f\u63a8\u8fdbHS-20094\u9488\u5bf92\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3001\u8d85\u91cd\/\u80a5\u80d6\u8005\u7684\u540e\u671f\u7814\u7a76\uff0c\u4ee5\u671f\u4e3a\u4e0a\u8ff0\u7c7b\u578b\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002<\/p>\n<\/p>\n

\u7ff0\u68ee\u5236\u836f\u662f\u4e2d\u56fd\u9886\u5148\u7684\u521b\u65b0\u9a71\u52a8\u578b\u5236\u836f\u4f01\u4e1a\uff0c\u4e0b\u5c5e\u8c6a\u68ee\u836f\u4e1a\u3001\u5e38\u5dde\u6052\u90a6\u836f\u4e1a\u3001\u7ff0\u68ee\u751f\u7269\u533b\u836f\u7b49\u5b50\u516c\u53f8\uff0c\u91cd\u70b9\u5173\u6ce8\u6297\u80bf\u7624\u3001\u6297\u611f\u67d3\u3001\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u3001\u4ee3\u8c22\u53ca\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u6cbb\u7597\u9886\u57df\uff0c\u81f4\u529b\u4e8e\u901a\u8fc7\u6301\u7eed\u521b\u65b0\u63d0\u9ad8\u4eba\u7c7b\u751f\u547d\u8d28\u91cf\u3002\u622a\u81f3\u76ee\u524d\uff0c\u7ff0\u68ee\u5236\u836f\u5df2\u4e0a\u5e027\u6b3e\u521b\u65b0\u836f\uff0c\u521b\u65b0\u836f\u8425\u6536\u5360\u6bd4\u8d85\u8fc760%\u3002<\/p>\n<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/p>\n<\/p>\n

\u30101\u3011diabetesatlas.org\/<\/p>\n<\/p>\n

\u30102\u3011\u4e2d\u534e\u7cd6\u5c3f\u75c5\u6742\u5fd72021\u5e744\u6708\u7b2c13\u5377\u7b2c4\u671fChin J Diabetes Mellitus,April 2021,Vol.13,No.4<\/p>\n<\/p>\n

\u30103\u3011Glucagon-like peptide 1 in health and disease.Nat Rev Endocrinol.2018 Jul;14(7):390-403.<\/p>\n<\/p>\n

\u30104\u3011GLP-1 receptor agonists and cardiovascular outcomes trials:An updated.Hellenic J Cardiol.2019 Nov-Dec;60(6):347-351.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

[db:\u6458\u8981]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5],"tags":[50],"_links":{"self":[{"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/posts\/2065"}],"collection":[{"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/unionmedin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2065"}],"version-history":[{"count":0,"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/posts\/2065\/revisions"}],"wp:attachment":[{"href":"https:\/\/unionmedin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/unionmedin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/unionmedin.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}