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New England Journal of Medicine\u4e0a\u62a5\u9053\u4e86\u76f8\u5173\u7814\u7a76\u6210\u679c\u3002Darnell\u8bf4\uff0c\u867d\u7136\u8fd9\u4e00\u53d1\u73b0\u5e76\u4e0d\u610f\u5473\u7740PRIME\u7ec6\u80de\u5bfc\u81f4\u4e86\u653b\u51fb\uff0c\u4f46\u8fd9\u4e9b\u6a21\u5f0f\u8868\u660e\uff0c\u5b83\u4eec\u662f\u5173\u8282\u708e\u75c7\u53d1\u4f5c\u7684\u7ec4\u6210\u90e8\u5206\u3002<\/div>\n<div><\/div>\n<div>\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\u4e86\u4e0e\u672a\u6210\u719f\u767d\u7ec6\u80de\u76f8\u5173\u7684RNA\u7b7e\u540d\uff0c\u8fd9\u4e9b\u672a\u6210\u719f\u767d\u7ec6\u80de\u5728PRIME\u7ec6\u80de\u6d3b\u8dc3\u524d\u51e0\u5929\u8fbe\u5230\u5cf0\u503c\u3002\u767d\u8840\u7403\u8d1f\u8d23\u542f\u52a8\u514d\u75ab\u6d3b\u52a8\u7684\u7ea7\u8054\u53cd\u5e94&#8211;\u62db\u52df\u5176\u4ed6\u708e\u75c7\u7ec6\u80de\u6765\u5b8c\u6210&#8211;\u529f\u80fd\u5931\u8c03\u7684\u767d\u8840\u7403\u4e0e\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6709\u5173\u3002Darnell\u8bf4\uff0c\u7efc\u5408\u6765\u770b\uff0c\u8fd9\u4e00\u53d1\u73b0\u8868\u660e\uff0cPRIME\u7ec6\u80de\u53ef\u4ee5\u88ab\u5f02\u5e38\u7684\u514d\u75ab\u7cfb\u7edf\u6d3b\u52a8\u52a8\u5458\u8d77\u6765\u3002<\/div>\n<div style=\"text-align: center\"><\/div>\n<div style=\"text-align: center\">\u56fe\u7247\u6765\u6e90\uff1aNEJM<\/div>\n<div><\/div>\n<div>\u4e4b\u524d\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u7c7b\u4f3c\u7684\u5f15\u8d77\u708e\u75c7\u7684\u7ed3\u7f14\u7ec4\u7ec7\u7ec6\u80de\u4f1a\u5bfc\u81f4\u5c0f\u9f20\u5173\u8282\u75be\u75c5\uff0c\u4f46\u8fd9\u662f\u7b2c\u4e00\u6b21\u5728\u4eba\u7c7b\u8840\u6db2\u4e2d\u53d1\u73b0\u8fd9\u79cd\u7ec6\u80de\u3002\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u7684\u98ce\u6e7f\u75c5\u75c5\u7406\u5b66\u5bb6Robert Winchester\u8bf4\uff0c\u8fd9\u4f7f\u5f97\u8fd9\u9879\u7814\u7a76\u53d8\u5f97&#8221;\u91cd\u8981&#8221;\uff0c\u56e0\u4e3a\u5b83\u53ef\u4ee5\u5f15\u5bfc\u7814\u7a76\u4eba\u5458\u6ce8\u610f\u5982\u4f55\u64cd\u7eb5\u8fd9\u4e9b\u7ec6\u80de\u6765\u63a7\u5236\u75be\u75c5\u3002\u7136\u800c\uff0cElewaut\u8b66\u544a\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u53ea\u662f\u7b2c\u4e00\u6b65\u3002\u8981\u786e\u5207\u5730\u77e5\u9053PRIME\u7ec6\u80de\u662f\u5982\u4f55\u5f71\u54cd\u7206\u53d1\u7684\uff0c\u8fd8\u9700\u8981&#8221;\u5927\u91cf&#8221;\u7684\u5b9e\u9a8c\u3002<\/div>\n<div><\/div>\n<div>\u5176\u4ed6\u4e13\u5bb6\u5bf9\u65b0\u7684\u7f13\u51b2\u89e3\u51b3\u65b9\u6848\u611f\u5230\u5174\u594b\u3002\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u7684\u98ce\u6e7f\u75c5\u5b66\u5bb6Stanley Cohen\u6ca1\u6709\u53c2\u4e0e\u8fd9\u9879\u7814\u7a76\uff0c\u4ed6\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u53ef\u4ee5\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u76d1\u6d4b\u60a3\u6709\u5176\u4ed6\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u60a3\u8005\u7684\u75be\u75c5\u6d3b\u52a8\uff0c\u8fd9\u4e9b\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6709\u589e\u6709\u51cf\uff0c\u5305\u62ec\u72fc\u75ae\u548c\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u3002Darnell\u8bf4\uff0c&#8221;\u4eba\u4eec\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u60f3\u8c61\u5c06\u6574\u4e2a\u65b9\u6cd5\u590d\u5236\u7c98\u8d34\u5230&#8221;\u5176\u4ed6\u75be\u75c5\u4e0a\u3002\u5176\u4e2d\u5305\u62ecCOVID-19\uff0c\u56e0\u4e3a\u4e25\u91cd\u75c5\u4f8b\u7684\u7279\u5f81\u662f\u5927\u91cf\u514d\u75ab\u7ec6\u80de\u3001\u51dd\u8840\u56e0\u5b50\u548c\u8840\u6db2\u4e2d\u7684\u5176\u4ed6\u708e\u75c7\u4fe1\u53f7\u3002Darnell\u5df2\u7ecf\u5f00\u59cb\u5bf9\u5728\u5bb6\u4e2d\u9694\u79bb\u7684\u60a3\u8005\u4e2d\u76d1\u6d4bCOVID-19\u7684\u65b9\u6cd5\u8fdb\u884c\u8c03\u6574\u3002<\/div>\n<div><\/div>\n<div>Darnell\u8bf4\uff0c\u8fd9\u4e9b\u53d1\u73b0\u53ef\u4ee5\u5e2e\u52a9\u7814\u7a76\u4eba\u5458&#8221;\u91c7\u53d6\u672c\u6770\u660e\u00b7\u5bcc\u5170\u514b\u6797\u7684\u65b9\u6cd5\u6765\u9884\u9632\u706b\u707e\uff1a\u4e00\u5206\u9884\u9632\uff0c\u800c\u4e0d\u662f\u4e00\u5206\u6cbb\u7597\u3002&#8221;Orange\u770b\u5230\u4e86\u5bf9\u5979\u7684\u75c5\u4eba\u66f4\u5177\u4f53\u7684\u597d\u5904\u3002\u5982\u679cPRIME\u7ec6\u80de\u6709\u52a9\u4e8e\u8bca\u65ad\u548c\u6cbb\u7597\uff0c&#8221;\u4f60\u81f3\u5c11\u53ef\u4ee5\u8ba1\u5212\u4f60\u7684\u751f\u6d3b\uff0c\u751a\u81f3\u963b\u6b62\u708e\u75c7\u7684\u5230\u6765\u3002&#8221; \uff08\uff09<\/div>\n<div><\/div>\n<div><span style=\"font-weight: bold\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/div>\n<div><span style=\"font-weight: bold\"><\/span><\/div>\n<div>Newly identified cell type may help predict\uff0c treat rheumatoid arthritis flares<\/div>\n<p><!--\/ewebeditor:page--><!--ewebeditor:page title=\"\"--><\/p>\n<div><span style=\"font-weight: bold\"><\/span><\/div>\n<div>RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares The New England Journal of Medicine&nbsp; &nbsp;DOI\uff1a 10.1056\/NEJMoa2004114<\/div>\n<div><span style=\"font-weight: bold\"><\/span><\/div>\n<div><span style=\"font-weight: bold\">Croft\uff0c A.P.\uff0c Campos\uff0c J.\uff0c Jansen\uff0c K. et al. Distinct fibroblast subsets drive inflammation and damage in arthritis. Nature 570\uff0c 246-251 (2019). https\uff1adoi.org\/10.1038\/s41586-019-1263-7<\/span><\/div>\n<div><span style=\"font-weight: bold\"><\/span><\/div>\n<div>Long-Term Effectiveness of Adalimumab in Patients with Rheumatoid Arthritis\uff1a An Observational Analysis from the Corrona Rheumatoid Arthritis Registry<\/div>\n<div><span style=\"font-weight: bold\"><\/span><\/div>\n<div>How does coronavirus kill\uff1f Clinicians trace a ferocious rampage through the body\uff0c from brain to toes<\/div>\n<p><!--\/ewebeditor:page--><\/div>\n<div style=\"color:#FF0000;font-weight:bold\">\n","protected":false},"excerpt":{"rendered":"<p>2020\u5e747\u670823\u65e5\u8baf \/ \/\u2014\u2014\u5f53Dana Orange\u7684\u75c5\u4eba\u7a81\u7136\u60a3\u4e0a\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e(RA)\u65f6\uff0c\u540e\u679c\u662f\u707e\u96be\u6027 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5],"tags":[],"_links":{"self":[{"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/posts\/22"}],"collection":[{"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/unionmedin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22"}],"version-history":[{"count":0,"href":"https:\/\/unionmedin.com\/index.php?rest_route=\/wp\/v2\/posts\/22\/revisions"}],"wp:attachment":[{"href":"https:\/\/unionmedin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/unionmedin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/unionmedin.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}