{"id":470,"date":"2020-09-15T10:47:10","date_gmt":"2020-09-15T02:47:10","guid":{"rendered":"http:\/\/unionmedin.com\/?p=470"},"modified":"2020-09-15T10:47:10","modified_gmt":"2020-09-15T02:47:10","slug":"nat-commun%ef%bc%9a%e7%a0%94%e7%a9%b6%e5%8f%91%e7%8e%b0%e5%a2%9e%e5%bc%ba%e6%8a%97%e7%99%8c%e5%85%8d%e7%96%ab%e5%8f%8d%e5%ba%94%e7%9a%84%e6%96%b0%e6%96%b9%e6%b3%95","status":"publish","type":"post","link":"https:\/\/unionmedin.com\/?p=470","title":{"rendered":"Nat&#160;Commun\uff1a\u7814\u7a76\u53d1\u73b0\u589e\u5f3a\u6297\u764c\u514d\u75ab\u53cd\u5e94\u7684\u65b0\u65b9\u6cd5"},"content":{"rendered":"<div>2020\u5e742\u670811\u65e5\u8baf \/ \/&#8211;Christopher E. Rudd\u535a\u58eb\u662f\u8499\u7279\u5229\u5c14\u5927\u5b66\u7684\u7814\u7a76\u5458\uff0c\u4ed6\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u7684\u7ec6\u80de\u6cbb\u7597\u65b9\u6cd5\uff0c\u53ef\u4ee5\u589e\u5f3aT\u6dcb\u5df4\u7ec6\u80de\u5bf9\u6076\u6027\u80bf\u7624\u7684\u514d\u75ab\u53cd\u5e94\u3002Christopher E. Rudd\u535a\u58eb\u662f\u8499\u7279\u5229\u5c14\u5927\u5b66\u5fae\u751f\u7269\u5b66\u3001\u611f\u67d3\u548c\u514d\u75ab\u5b66\u7cfb\u7684\u6559\u6388\uff0c\u4e5f\u662fCR-HMR\u514d\u75ab\u6cbb\u7597\u90e8\u95e8\u7684\u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\u9879\u76ee\u7ec4\u4e3b\u4efb\u3002\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u8fd1\u671f\u53d1\u8868\u5728\u6743\u5a01\u6742\u5fd7\u300aNature Communications\u300b\u4e0a\u3002<\/div>\n<div style=\"text-align: center\"><img decoding=\"async\" src=\"http:cache3.bioon.com\/webeditor\/uploadfile\/202002\/20200211231159618_s.png\" \/><\/div>\n<div style=\"text-align: center\">\u56fe\u7247\u6765\u6e90\uff1aNature Communications<\/div>\n<div><\/div>\n<div>Rudd\u8bf4\uff1a&#8221;\u6211\u4eec\u7684\u5de5\u4f5c\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u7684T\u7ec6\u80de\u86cb\u767d\uff0c\u5b83\u4e0e\u68c0\u6d4b\u548c\u54cd\u5e94\u764c\u75c7\u6297\u539f\u7684\u5173\u952e\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u3002\u6211\u4eec\u5229\u7528\u8fd9\u4e9b\u53d1\u73b0\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u5f62\u5f0f\u7684\u514d\u75ab\u7597\u6cd5\uff0c\u5728\u8fd9\u79cd\u7597\u6cd5\u4e2d\uff0cT\u7ec6\u80de\u7684\u8fc7\u5ea6\u6fc0\u6d3b\u4f7f\u5b83\u4eec\u80fd\u591f\u7a7f\u900f\u5e76\u653b\u51fb\u80bf\u7624\u3002\u8fd9\u4e00\u53d1\u73b0\u8868\u660e\uff0c\u8c03\u8282\u8bc6\u522b\u51fa\u7684\u86cb\u767d\u8d28\u53ef\u4ee5\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\uff0c\u5bfc\u81f4\u764c\u7ec6\u80de\u7684\u7834\u574f\u3002&#8221;<\/div>\n<div><\/div>\n<div>\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8fd9\u79cd\u65b0\u7684\u514d\u75ab\u7597\u6cd5\u5bf9\u767d\u8840\u75c5\u548c\u67d0\u4e9b\u76ae\u80a4\u764c\u7684\u7597\u6548\u5df2\u5728\u52a8\u7269\u8eab\u4e0a\u5f97\u5230\u8bc1\u5b9e\u3002\u4e0b\u4e00\u9636\u6bb5\u5c06\u662f\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/div>\n<div><\/div>\n<div>&#8220;\u8fd9\u4e00\u53d1\u73b0\u662f\u4e00\u9879\u79d1\u5b66\u7a81\u7834\uff0c\u5b83\u5c06\u663e\u7740\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\u6d88\u706d\u764c\u7ec6\u80de\u7684\u6709\u6548\u6027\uff0c&#8221;\u7ec6\u80de\u6cbb\u7597\u548cCR-HMR\u5353\u8d8a\u4e2d\u5fc3\u7684\u79d1\u5b66\u548c\u533b\u5b66\u4e3b\u4efbDenis-Claude Roy\u535a\u58eb\u8bf4\u3002<\/div>\n<div><\/div>\n<div>\u6700\u7ec8\uff0c\u8fd9\u79cd\u65b9\u6cd5\u4e5f\u53ef\u4ee5\u63d0\u9ad8CAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u6709\u6548\u6027\uff0c\u76ee\u524d\u8fd9\u79cd\u6cbb\u7597\u65b9\u6cd5\u6b63\u5728Hopital Maisonneuve-Rosemont\u533b\u9662\u4f7f\u7528\u3002<\/div>\n<div><\/div>\n<div>\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n<div><\/div>\n<div>Youg Raj Thaker et al\uff0c GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity\uff0c Nature Communications (2019).&nbsp; DOI\uff1a 10.1038\/s41467-019-12544-4<\/div>\n<\/div>\n<div style=\"color:#FF0000;font-weight:bold\">\n","protected":false},"excerpt":{"rendered":"<p>2020\u5e742\u670811\u65e5\u8baf \/ \/&#8211;Christopher E. 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