{"id":484,"date":"2020-09-17T18:44:25","date_gmt":"2020-09-17T10:44:25","guid":{"rendered":"http:\/\/unionmedin.com\/?p=484"},"modified":"2020-09-17T18:44:25","modified_gmt":"2020-09-17T10:44:25","slug":"2019%e5%9b%9e%e7%9c%b8%ef%bc%9a%e7%9d%a1%e7%9c%a0%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e7%9b%98%e7%82%b9","status":"publish","type":"post","link":"https:\/\/unionmedin.com\/?p=484","title":{"rendered":"2019\u56de\u7738\uff1a\u7761\u7720\u7814\u7a76\u8fdb\u5c55\u76d8\u70b9"},"content":{"rendered":"<p><!--ewebeditor:page title=\"\"--><\/p>\n<div>2019\u5e7412\u670827\u65e5\u8baf \/ 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Commun\uff1a\u65b0\u7814\u7a76\u53d1\u73b0\u7f3a\u4e4f\u7761\u7720\u7684\u9057\u4f20\u673a\u5236<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1038\/s41467-019-09576-1<\/div>\n<div><\/div>\n<div>\u300aNature Communications\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u627e\u5230\u4e86\u7761\u7720\u8d28\u91cf\u4e0e\u9057\u4f20\u80cc\u666f\u4e4b\u95f4\u7684\u8054\u7cfb\u3002\u8be5\u7814\u7a76\u8c03\u67e5\u4e86\u6765\u81ea\u82f1\u56fd\u751f\u7269\u94f6\u884c\u768485\uff0c670\u540d\u53c2\u4e0e\u8005\u548c\u6765\u81ea\u5176\u4ed6\u4e09\u9879\u7814\u7a76\u76845\uff0c819\u540d\u4e2a\u4eba\u7684\u6570\u636e\uff0c\u8fd9\u4e9b\u7814\u7a76\u4f7f\u7528\u52a0\u901f\u5ea6\u8ba1 &#8211; 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&#8211; \u5e73\u5747\u81c0\u56f4\u7ea6100cm\u7684\u4eba\u6bcf1cm\u8170\u56f4\u51cf\u5c11\u7ea64\u79d2\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u53d1\u73b0\u4e0e\u7761\u7720\u8d28\u91cf\u76f8\u5173\u7684\u9057\u4f20\u533a\u57df\u4e5f\u4e0e\u8840\u6e05\u7d20\uff085-\u7f9f\u8272\u80fa\uff09\u7684\u4ea7\u751f\u6709\u5173\u3002<\/div>\n<div><\/div>\n<div>\u30102\u3011Nature\uff1a\u91cd\u5927\u8fdb\u5c55\uff01\u63ed\u793a\u6c27\u5316\u5e94\u6fc0\u5bfc\u81f4\u7761\u7720\u7684\u5206\u5b50\u673a\u5236<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1038\/s41586-019-1034-5<\/div>\n<div><\/div>\n<div>\u5728\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u82f1\u56fd\u725b\u6d25\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u6c27\u5316\u5e94\u6fc0\u5982\u4f55\u5bfc\u81f4\u7761\u7720\u3002\u6c27\u5316\u5e94\u6fc0\u88ab\u8ba4\u4e3a\u662f\u6211\u4eec\u8870\u8001\u7684\u539f\u56e0\u4e4b\u4e00\uff0c\u4e5f\u662f\u9000\u5316\u6027\u75be\u75c5\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u8fd9\u4e00\u53d1\u73b0\u8ba9\u6211\u4eec\u66f4\u8fdb\u4e00\u6b65\u4e86\u89e3\u7761\u7720\u4ecd\u7136\u795e\u79d8\u7684\u529f\u80fd\uff0c\u5e76\u4e3a\u6cbb\u7597\u7761\u7720\u969c\u788d\u63d0\u4f9b\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u8fd9\u4e5f\u53ef\u80fd\u89e3\u91ca\u4e86\u4e3a\u4f55\u957f\u671f\u7761\u7720\u4e0d\u8db3\u4f1a\u7f29\u77ed\u751f\u547d\u3002<\/div>\n<div><\/div>\n<div>\u8bba\u6587\u901a\u8baf\u4f5c\u8005\u3001\u725b\u6d25\u5927\u5b66\u795e\u7ecf\u56de\u8def\u4e0e\u884c\u4e3a\u4e2d\u5fc3\u4e3b\u4efbGero Miesenb\uff1fck\u6559\u6388\u8bf4\uff0c&#8221;\u6c27\u6c14\u7f50\u5e26\u6709\u7206\u70b8\u5371\u9669\u6807\u7b7e\u5e76\u975e\u5076\u7136\uff1a\u4e0d\u53d7\u63a7\u5236\u7684\u71c3\u70e7\u662f\u5371\u9669\u7684\u3002\u5305\u62ec\u4eba\u7c7b\u5728\u5185\u7684\u52a8\u7269\u5728\u4f7f\u7528\u5b83\u4eec\u547c\u5438\u7684\u6c27\u6c14\u5c06\u98df\u7269\u8f6c\u5316\u4e3a\u80fd\u91cf\u65f6\u9762\u4e34\u7740\u7c7b\u4f3c\u7684\u98ce\u9669\uff1a\u4e0d\u5b8c\u5168\u7684\u71c3\u70e7\u5bfc\u81f4\u7ec6\u80de\u4e2d\u7684&#8217;\u6c27\u5316\u5e94\u6fc0&#8217;\u3002\u8fd9\u88ab\u8ba4\u4e3a\u662f\u5bfc\u81f4\u8870\u8001\u7684\u539f\u56e0\uff0c\u4e5f\u662f\u5bfc\u81f4\u56f0\u6270\u7740\u6211\u4eec\u665a\u5e74\u7684\u9000\u884c\u6027\u75be\u75c5\u7684\u7f6a\u9b41\u7978\u9996\u3002\u6211\u4eec\u7684\u65b0\u7814\u7a76\u8868\u660e\u6c27\u5316\u5e94\u6fc0\u4e5f\u4f1a\u6fc0\u6d3b\u63a7\u5236\u6211\u4eec\u662f\u5426\u8fdb\u5165\u7761\u7720\u72b6\u6001\u7684\u795e\u7ecf\u5143\u3002&#8221;<\/div>\n<div style=\"text-align: center\"><img decoding=\"async\" src=\"http:cache3.bioon.com\/webeditor\/uploadfile\/201912\/20191208211951729.png\" \/><\/div>\n<div style=\"text-align: center\">\u56fe\u7247\u6765\u6e90\uff1aWww.pixabay.com<\/div>\n<div><\/div>\n<div>\u30103\u3011J Neurosci\uff1a\u53d1\u73b0\u5c0f\u9f20\u5728\u7761\u7720\u548c\u9192\u7740\u65f6\u90fd\u6d3b\u8dc3\u7684\u8111\u7ec6\u80de<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1523\/JNEUROSCI.0305-19.2019<\/div>\n<div><\/div>\n<div>\u7814\u7a76\u4eba\u5458\u7ed8\u5236\u4e86\u96c4\u6027\u548c\u96cc\u6027\u8001\u9f20\u5728\u7761\u7720\u548c\u63a2\u7d22\u65b0\u4e8b\u7269\u65f6\u5927\u8111\u6df1\u5904\u5355\u4e2a\u795e\u7ecf\u5143\u7684\u6d3b\u52a8\u56fe\u8c31\u3002\u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0c\u67d0\u4e9b\u7ec6\u80de\u53ef\u80fd\u4fc3\u8fdb\u8bb0\u5fc6\u7684\u5f62\u6210\u3002<\/div>\n<div><\/div>\n<div>\u9ed1\u8272\u7d20\u6d53\u96c6\u6fc0\u7d20(Melanin-concentrating hormone\uff0cMCH)\u795e\u7ecf\u5143\u5728\u5feb\u901f\u773c\u52a8\u7761\u7720\u671f\u95f4\u662f\u6d3b\u8dc3\u7684\uff0c\u8fd9\u662f\u7761\u7720\u8fc7\u7a0b\u4e2d\u505a\u68a6\u7684\u9636\u6bb5&#8211;\u4e5f\u8bb8\u4e5f\u662f\u8bb0\u5fc6\u5de9\u56fa\u7684\u9636\u6bb5\u3002\u5357\u5361\u7f57\u83b1\u7eb3\u533b\u79d1\u5927\u5b66\u548c\u8036\u9c81\u5927\u5b66\u533b\u5b66\u9662\u7684Carlos Blanco\u3001Priyattam Shiromani\u53ca\u4ed6\u4eec\u7684\u540c\u4e8b\u62a5\u544a\u8bf4\uff0c\u5f53\u8001\u9f20\u63a2\u7d22\u6d3b\u9875\u5939\u6216\u74f6\u76d6\u7b49\u6709\u8da3\u7684\u7269\u4f53\u65f6\uff0c\u670970%\u7684\u5feb\u901f\u773c\u52a8\u7761\u7720\u4e2d\u5f3a\u70c8\u6fc0\u6d3b\u7684MCH\u795e\u7ecf\u5143\u4e5f\u53d8\u5f97\u6d3b\u8dc3\u8d77\u6765\u3002\u901a\u8fc7\u8bb0\u5f55\u6210\u5bf9\u7684MCH\u795e\u7ecf\u5143\u7684\u6d3b\u52a8\uff0c\u7814\u7a76\u4eba\u5458\u63ed\u793a\u4e86\u4e00\u79cd\u5355\u7ec6\u80de\u6d3b\u52a8\u7684\u6a21\u5f0f\uff0c\u53ef\u4ee5\u7528\u6765\u6bd4\u8f83\u4e0d\u540c\u5065\u5eb7\u548c\u75be\u75c5\u72b6\u6001\u4e0b\u8fd9\u4e2a\u7f51\u7edc\u7684\u529f\u80fd\u3002<\/div>\n<div><\/div>\n<div>\u30104\u3011JINS\uff1a\u8981\u60f3\u6539\u5584\u5de5\u4f5c\u8bb0\u5fc6\uff1f\u4fdd\u6301\u826f\u597d\u7684\u7761\u7720\u548c\u60c5\u7eea\u81f3\u5173\u91cd\u8981\uff01<\/div>\n<div><\/div>\n<div>DOI\uff1a10.1017\/S1355617719000183<\/div>\n<div><\/div>\n<div>\u5728\u4e00\u9879\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\u5de5\u4f5c\u8bb0\u5fc6\u6216\u8bb8\u548c\u4e09\u79cd\u5065\u5eb7\u76f8\u5173\u56e0\u5b50\u4e4b\u95f4\u5b58\u5728\u5bc6\u5207\u5173\u8054\uff0c\u8fd9\u4e09\u79cd\u5065\u5eb7\u76f8\u5173\u56e0\u5b50\u5305\u62ec\u7761\u7720\u3001\u5e74\u9f84\u548c\u60c5\u611f\u4f4e\u843d\uff0c\u6bcf\u4e00\u79cd\u56e0\u7d20\u90fd\u4e0e\u5de5\u4f5c\u8bb0\u5fc6\u7684\u4e0d\u540c\u65b9\u9762\u5b58\u5728\u5173\u8054\u3002<\/div>\n<div><\/div>\n<div>\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u5e74\u9f84\u4e0e\u5de5\u4f5c\u8bb0\u5fc6\u7684\u5b9a\u6027\u65b9\u9762&#8211;\u4e5f\u5c31\u662f\u8bb0\u5fc6\u6709\u591a\u5f3a\u6216\u8005\u591a\u51c6\u786e&#8211;\u5b58\u5728\u8d1f\u76f8\u5173\u5173\u7cfb\uff0c\u6362\u53e5\u8bdd\u8bf4\uff0c\u4e00\u4e2a\u4eba\u7684\u5e74\u9f84\u8d8a\u5927\uff0c\u5176\u8bb0\u5fc6\u529b\u5c31\u8d8a\u5f31\u800c\u4e14\u8d8a\u4e0d\u51c6\u786e\uff1b\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u8f83\u5dee\u7684\u7761\u7720\u8d28\u91cf\u548c\u60c5\u7eea\u4f4e\u8ff7\u4e5f\u4e0e\u80fd\u591f\u8bb0\u4f4f\u6b64\u524d\u6240\u7ecf\u5386\u7684\u65f6\u95f4\u7684\u53ef\u80fd\u6027\u4e0b\u964d\u76f4\u63a5\u76f8\u5173\uff0c\u8fd9\u5c31\u662f\u5de5\u4f5c\u8bb0\u5fc6\u7684\u5b9a\u91cf\u65b9\u9762\u3002<\/div>\n<div><\/div>\n<div>\u30105\u3011\u4e0d\u5bb9\u5c0f\u89d1\uff01\u4ec5\u4ec516\u5206\u949f\u7684\u7761\u7720\u4e0d\u8db3\u5c31\u4f1a\u5f71\u54cd\u7b2c\u4e8c\u5929\u7684\u5de5\u4f5c\u6ce8\u610f\u529b\uff01<\/div>\n<div><\/div>\n<div>DOI\uff1a10.1016\/j.sleh.2019.01.007<\/div>\n<div><\/div>\n<div>\u4f60\u6700\u8fd1\u6709\u8fc7\u4e00\u6b21\u7531\u4e8e\u767d\u5929\u6253\u76f9\u800c\u505a\u4e86\u9519\u8bef\u7684\u51b3\u5b9a\u7684\u7ecf\u5386\u4e48\uff1f\u8fd9\u6216\u8bb8\u5e76\u4e0d\u662f\u5173\u4e4e\u4f60\u7684\u5de5\u4f5c\uff0c\u800c\u662f\u4e0e\u7761\u7720\u6709\u5173\uff0c\u4f46\u8fd9\u5e76\u4e0d\u5b8c\u5168\u662f\u4f60\u7684\u9519\uff0c\u5f88\u591a\u7814\u7a76\u4eba\u5458\u90fd\u5728\u7814\u7a76\u5065\u5eb7\u548c\u673a\u4f53\u8870\u8001\u7684\u591a\u4e2a\u65b9\u9762\uff0c\u6700\u8fd1\u6709\u7814\u7a76\u8868\u660e\uff0c\u7761\u7720\u4e0d\u597d\u6216\u8bb8\u4f1a\u5f71\u54cd\u673a\u4f53\u7684\u5224\u65ad\u529b\uff0c\u4ece\u800c\u5bfc\u81f4\u5de5\u4f5c\u5931\u8bef\u548c\u6ce8\u610f\u529b\u5206\u6563\uff0c\u800c\u5c06\u7761\u7720\u653e\u5728\u9996\u4f4d\u6216\u8bb8\u80fd\u591f\u63d0\u9ad8\u6211\u4eec\u5728\u5de5\u4f5c\u4e2d\u7684\u8ba4\u77e5\u80fd\u529b\u3002<\/div>\n<div><\/div>\n<div>\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u5728\u6bd4\u5e73\u65f6\u7761\u7720\u8d28\u91cf\u66f4\u77ed\u3001\u8d28\u91cf\u66f4\u5dee\u7684\u65e5\u5b50\u91cc\uff0c\u5de5\u4f5c\u4eba\u5458\u90fd\u62a5\u544a\u4e86\u66f4\u591a\u7684\u8ba4\u77e5\u5e72\u6270\uff0c\u5728\u53c2\u4e0e\u8005\u4e2d\uff0c\u76f8\u6bd4\u5e73\u65f6\u5c11\u776116\u5206\u949f\u7684\u7761\u7720\u4e0e\u7b2c\u4e8c\u5929\u4e2a\u4eba\u8ba4\u77e5\u5e72\u6270\u91cf\u8868\u4e0a\u7684\u53e6\u4e00\u4e2a\u70b9\u5b58\u5728\u4e00\u5b9a\u7684\u76f8\u5173\u6027\u3002<\/div>\n<p><!--\/ewebeditor:page--><!--ewebeditor:page title=\"\"--><\/p>\n<div><\/div>\n<div>\u30106\u3011Exper Physiol\uff1a\u7761\u7720\u4e0d\u8db3\u4f1a\u5f71\u54cd\u673a\u4f53\u4e2dmicroRNA\u7684\u529f\u80fd \u8fdb\u800c\u635f\u4f24\u5fc3\u8840\u7ba1\u5065\u5eb7\uff01<\/div>\n<div><\/div>\n<div>DOI\uff1a10.1113\/EP087469<\/div>\n<div><\/div>\n<div>\u8fd1\u4e9b\u5e74\u6765\uff0c\u5927\u91cf\u7814\u7a76\u8868\u660e\uff0c\u7761\u7720\u4e0d\u8db3\u7684\u4eba\u7fa4\u60a3\u4e2d\u98ce\u548c\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u98ce\u9669\u8f83\u9ad8\uff1b\u5728\u4e00\u9879\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u79d1\u7f57\u62c9\u591a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u6bcf\u665a\u7761\u7720\u4e0d\u8db37\u4e2a\u5c0f\u65f6\u7684\u4e2a\u4f53\u673a\u4f53\u8840\u6db2\u4e2d\u4e09\u79cd\u751f\u7406\u5b66\u8c03\u8282\u5b50\uff08microRNAs\uff09\u7684\u6c34\u5e73\u8f83\u4f4e\uff0c\u5176\u80fd\u5f71\u54cd\u57fa\u56e0\u8868\u8fbe\u5e76\u5728\u7ef4\u6301\u8840\u7ba1\u5065\u5eb7\u4e0a\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\u3002<\/div>\n<div><\/div>\n<div>\u5728\u53e6\u5916\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u6bcf\u665a\u77616\u4e2a\u5c0f\u65f6\u7684\u6210\u5e74\u7537\u6027\u673a\u4f53\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u5f02\u5e38\uff0c\u4e14\u5176\u52a8\u8109\u5e76\u4e0d\u50cf\u90a3\u4e9b\u7761\u7720\u5145\u8db3\u7684\u4eba\u7fa4\u80fd\u591f\u6b63\u5e38\u8fdb\u884c\u6269\u5f20\u548c\u6536\u7f29\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u5e76\u4e0d\u6e05\u695a\u8bf1\u53d1\u8fd9\u79cd\u5f02\u5e38\u80cc\u540e\u7684\u673a\u5236\u3002MicroRNAs\u662f\u4e00\u79cd\u80fd\u591f\u6291\u5236\u7ec6\u80de\u4e2d\u7279\u5b9a\u86cb\u767d\u57fa\u56e0\u8868\u8fbe\u7684\u5c0f\u578b\u5206\u5b50\uff0c\u5982\u4eca\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u5927\u91cf\u7814\u7a76\u6765\u9610\u660emicroRNAs\u5206\u5b50\u5728\u5fc3\u8840\u7ba1\u7cfb\u7edf\u4e2d\u7684\u529f\u80fd\u53ca\u5176\u5bf9\u673a\u4f53\u5fc3\u8840\u7ba1\u5065\u5eb7\u7684\u5f71\u54cd\uff0c\u800c\u4e14\u7814\u7a76\u4eba\u5458\u4e5f\u6b63\u5728\u5f00\u53d1\u6cbb\u7597\u5305\u62ec\u764c\u75c7\u5728\u5185\u7684\u4e00\u7cfb\u5217\u75be\u75c5\uff0c\u4ece\u800c\u7ea0\u6b63\u60a3\u8005\u673a\u4f53\u4e2d\u635f\u4f24\u7684microRNA\u6807\u8bb0\u3002<\/div>\n<div><\/div>\n<div>\u30107\u3011\u7761\u7720\u8d28\u91cf\u8f83\u5dee\u6216\u4e0e\u8425\u517b\u7269\u8d28\u6444\u5165\u6c34\u5e73\u4e0d\u8db3\u6709\u5173<\/div>\n<div><\/div>\n<div>P06-103-19 &#8211; Analysis of NHANES 2005-2016 Data Showed Significant Association Between Micro and Macronutrient Intake and Various Sleep Variables<\/div>\n<div><\/div>\n<div>\u8bb8\u591a\u7f8e\u56fd\u4eba\u7684\u7761\u7720\u91cf\u4f4e\u4e8e\u5efa\u8bae\u7684\u7761\u7720\u91cf\uff0c\u800c\u4e14\u5f88\u591a\u4eba\u4e5f\u5e76\u4e0d\u4f1a\u6444\u5165\u63a8\u8350\u5242\u91cf\u7684\u91cd\u8981\u7ef4\u751f\u7d20\u548c\u77ff\u7269\u8d28\uff0c\u8fd1\u6765\u6709\u7814\u7a76\u8868\u660e\u7761\u7720\u6216\u8bb8\u548c\u8425\u517b\u7269\u8d28\u7684\u6444\u5165\u4e4b\u95f4\u5b58\u5728\u4e00\u5b9a\u5173\u8054\u3002\u8fd9\u9879\u7814\u7a76\u57fa\u4e8e\u7f8e\u56fd\u56fd\u5bb6\u5065\u5eb7\u4e0e\u8425\u517b\u8c03\u67e5\u8ba1\u5212\uff08NHANES\uff09\u7684\u6570\u636e\uff0c\u8be5\u8ba1\u5212\u662f\u7f8e\u56fd\u6210\u5e74\u4eba\u7684\u5168\u56fd\u4ee3\u8868\u6027\u6570\u636e\u3002<\/div>\n<div><\/div>\n<div>\u7814\u7a76\u8005\u6307\u51fa\uff0c\u4e0e\u6bcf\u665a\u7761\u7720\u8d85\u8fc77\u4e2a\u5c0f\u65f6\u7684\u4eba\u7fa4\u76f8\u6bd4\uff08\u7f8e\u56fdCDC\uff09\uff0c\u5e73\u5747\u6bcf\u665a\u7761\u7720\u4e0d\u8db37\u4e2a\u5c0f\u65f6\u7684\u4eba\u7fa4\u6d88\u8017\u7684\u7ef4\u751f\u7d20A\u3001D\u548cB1\u7684\u6c34\u5e73\u8f83\u4f4e\uff0c\u800c\u4e14\u6444\u5165\u7684\u9541\u3001\u70df\u9178\u3001\u9499\u3001\u950c\u548c\u78f7\u7684\u6c34\u5e73\u4e5f\u8f83\u4f4e\u3002\u76f8\u6bd4\u7537\u6027\u800c\u8a00\uff0c\u5728\u5973\u6027\u7fa4\u4f53\u4e2d\uff0c\u5176\u7761\u7720\u8d28\u91cf\u8f83\u5dee\u4e0e\u6444\u5165\u8425\u517b\u7269\u8d28\u7684\u591a\u5c11\u6709\u5173\uff0c\u5982\u679c\u5973\u6027\u670d\u7528\u81b3\u98df\u8865\u5145\u5242\u7684\u8bdd\uff0c\u8fd9\u4e2a\u6570\u5b57\u5c31\u4f1a\u51cf\u5c11\uff0c\u8fd9\u5c31\u8868\u660e\uff0c\u81b3\u98df\u8865\u5145\u5242\u80fd\u591f\u5e2e\u52a9\u586b\u8865\u4e00\u4e2a\u4eba\u996e\u98df\u4e2d\u5e76\u4e0d\u80fd\u63d0\u4f9b\u5fc5\u8981\u8425\u517b\u7684\u7a7a\u767d\u3002<\/div>\n<div style=\"text-align: center\"><img decoding=\"async\" src=\"http:cache3.bioon.com\/webeditor\/uploadfile\/201912\/20191208212014343.jpg\" \/><\/div>\n<div style=\"text-align: center\">\u56fe\u7247\u6765\u6e90\uff1atheconversation<\/div>\n<div><\/div>\n<div>\u30108\u3011JACC\uff1a50\u4e07\u4eba\u5927\u6570\u636e\uff1a\u7761\u7720\u8fc7\u591a\u6216\u8fc7\u5c11\u90fd\u4f1a\u589e\u52a0\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u98ce\u9669\uff01<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1016\/j.jacc.2019.07.022<\/div>\n<div><\/div>\n<div>\u7f8e\u56fd\u79d1\u7f57\u62c9\u591a\u5927\u5b66\u535a\u5c14\u5fb7\u5206\u6821\u5bf9\u8fd150\u4e07\u4eba\u8fdb\u884c\u7684\u4e00\u9879\u6700\u65b0\u7814\u7a76\u663e\u793a\uff0c\u5373\u4f7f\u4f60\u4e0d\u5438\u70df\uff0c\u7ecf\u5e38\u953b\u70bc\uff0c\u4e5f\u6ca1\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u9057\u4f20\u6613\u611f\uff0c\u7761\u7720\u4e0d\u8db3\u6216\u7761\u7720\u8fc7\u591a\u4e5f\u4f1a\u589e\u52a0\u4f60\u60a3\u5fc3\u810f\u75c5\u7684\u98ce\u9669\u3002<\/div>\n<div><\/div>\n<div>\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5206\u6790\u4e8646.1\u4e07\u540d\u5e74\u9f84\u572840\u5c81\u81f369\u5c81\u4e4b\u95f4\u3001\u4ece\u672a\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u82f1\u56fd\u751f\u7269\u94f6\u884c(Biobank)\u53c2\u4e0e\u8005\u7684\u57fa\u56e0\u4fe1\u606f\u3001\u81ea\u6211\u62a5\u544a\u7684\u7761\u7720\u4e60\u60ef\u548c\u533b\u7597\u8bb0\u5f55\uff0c\u7136\u540e\u5bf9\u4ed6\u4eec\u8fdb\u884c\u4e867\u5e74\u7684\u8ddf\u8e2a\u8c03\u67e5\u3002\u4e0e\u6bcf\u665a\u7761\u77206\u81f39\u5c0f\u65f6\u7684\u4eba\u76f8\u6bd4\uff0c\u7761\u7720\u4e0d\u8db36\u5c0f\u65f6\u7684\u4eba\u5728\u7814\u7a76\u671f\u95f4\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u51e0\u7387\u8981\u9ad8\u51fa20%\u3002\u90a3\u4e9b\u7761\u7720\u65f6\u95f4\u8d85\u8fc79\u5c0f\u65f6\u7684\u4eba\u670934%\u7684\u53ef\u80fd\u6027\u3002\u5f53\u7814\u7a76\u4eba\u5458\u53ea\u5bf9\u6709\u5fc3\u810f\u75c5\u9057\u4f20\u503e\u5411\u7684\u4eba\u8fdb\u884c\u7814\u7a76\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0\u6bcf\u665a\u77616\u52309\u4e2a\u5c0f\u65f6\u53ef\u4ee5\u5c06\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u98ce\u9669\u964d\u4f4e18%\u3002<\/div>\n<div><\/div>\n<div>\u30109\u3011Neuron\uff1a\u91cd\u5927\u7a81\u7834\uff01\u7ee710\u5e74\u6f5c\u5fc3\u7814\u7a76\u540e \u79d1\u5b66\u5bb6\u7ec8\u9274\u522b\u51fa\u7b2c\u4e8c\u4e2a&#8221;\u5929\u751f\u77ed\u7761\u7720&#8221;\u57fa\u56e0<\/div>\n<div><\/div>\n<div>DOI\uff1a10.1016\/j.neuron.2019.07.026<\/div>\n<div><\/div>\n<div>\u7ee710\u5e74\u6f5c\u5fc3\u7814\u7a76\u540e\uff0c\u6765\u81ea\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u7ec8\u4e8e\u9274\u522b\u51fa\u4e86\u7b2c\u4e8c\u4e2a\u4fc3\u8fdb&#8221;\u5929\u751f\u77ed\u65f6\u95f4\u7761\u7720&#8221;\u7684\u5173\u952e\u57fa\u56e0\uff0c\u6b64\u524d\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u7b2c\u4e00\u4e2a\u4fc3\u8fdb&#8221;\u5929\u751f\u77ed\u65f6\u95f4\u7761\u7720&#8221;\u7684\u57fa\u56e0\uff0c\u5929\u751f\u77ed\u65f6\u95f4\u7761\u7720\uff0c\u5373\u4e2a\u4f53\u7ec8\u751f\u6bcf\u665a\u7684\u7761\u7720\u65f6\u95f4\u4ec5\u4e3a4-6\u4e2a\u5c0f\u65f6\uff0c\u4f46\u5176\u673a\u4f53\u4ecd\u7136\u5f97\u5230\u4e86\u5145\u8db3\u7684\u4f11\u606f\u3002<\/div>\n<div><\/div>\n<div>\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u627e\u5230\u4e86\u4e00\u4e2a\u5305\u62ec\u8fde\u7eed\u4e09\u4ee3\u5929\u751f\u77ed\u7761\u7720\u8005\u7684\u5bb6\u5ead\uff0c\u5176\u673a\u4f53\u4e2d\u5e76\u4e0d\u643a\u5e26DEC2\u57fa\u56e0\u7a81\u53d8\uff0c\u968f\u540e\u7814\u7a76\u4eba\u5458\u5229\u7528\u57fa\u56e0\u6d4b\u5e8f\u548c\u8fde\u9501\u5206\u6790\u65b9\u6cd5\u5bf9\u8be5\u5bb6\u65cf\u4e2a\u4f53\u673a\u4f53\u7684\u57fa\u56e0\u7ec4\u8fdb\u884c\u4e86\u5173\u8054\u6027\u5206\u6790\uff0c\u8fd9\u4e9b\u6280\u672f\u80fd\u5e2e\u52a9\u7814\u7a76\u8005\u5bfb\u627e\u5230\u4e0e\u7279\u5b9a\u7279\u6027\u76f8\u5173\u7684\u7a81\u53d8\u5728\u67d3\u8272\u4f53\u4e2d\u7684\u5177\u4f53\u4f4d\u7f6e\uff0c\u7814\u7a76\u8005\u9274\u522b\u51fa\u4e86ADRB1\u57fa\u56e0\u7684\u5355\u78b1\u57fa\u7a81\u53d8\uff0c\u5176\u4e0eDEC2\u7a81\u53d8\u4e00\u6837\uff0c\u90fd\u4e0e\u5929\u751f\u77ed\u7761\u7720\u76f4\u63a5\u76f8\u5173\u3002<\/div>\n<div><\/div>\n<div>\u301010\u3011Sleep Med\uff1a\u7761\u7720\u8fd8\u4f1a\u53d7\u5230\u6027\u522b\uff0c\u5730\u57df\u4e0e\u5e74\u9f84\u7684\u5f71\u54cd\uff1f<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1016\/j.sleep.2019.07.024<\/div>\n<div><\/div>\n<div>\u6839\u636e\u4e00\u9879\u5173\u4e8e\u7761\u7720\u7684\u5168\u7403\u6027\u5e7f\u6cdb\u7814\u7a76\uff0c\u4f5c\u8005\u53d1\u73b0\u4eba\u4eec\u7684\u7761\u7720\u65f6\u95f4\u4f1a\u968f\u7740\u5e74\u9f84\uff0c\u5730\u7406\u533a\u57df\u548c\u6027\u522b\u7684\u4e0d\u540c\u4ea7\u751f\u5dee\u5f02\u3002<\/div>\n<div><\/div>\n<div>\u6309\u5730\u57df\u6765\u770b\uff0c\u6b27\u6d32\u548c\u5317\u7f8e\u7684\u4eba\u7761\u7720\u65f6\u95f4\u6700\u957f\uff0c\u800c\u4e9a\u6d32\u56fd\u5bb6\u7684\u7761\u7720\u65f6\u95f4\u6700\u77ed\u3002\u4e2d\u4e1c\u5730\u533a\u4eba\u4eec\u7761\u89c9\u65f6\u95f4\u6700\u665a\uff0c\u800c\u6700\u65e9\u5f00\u59cb\u4f11\u606f\u7684\u5219\u662f\u5728\u5927\u6d0b\u6d32\u5c45\u4f4f\u7684\u4eba\u4eec\u3002\u6309\u6027\u522b\u6765\u770b\uff0c\u5e74\u8f7b\u7684\u5973\u4eba\u6bd4\u5e74\u8f7b\u7684\u7537\u4eba\u7761\u5f97\u66f4\u591a\uff0c\u524d\u8005\u7761\u7720\u7684\u65f6\u95f4\u4e5f\u65e9\u4e00\u4e9b\u3002<\/div>\n<div><\/div>\n<div>\u301011\u3011Cell\uff1a\u8c03\u8282\u5927\u8111\u7761\u7720\u7684\u6ce2\u52a8\u80fd\u591f\u6709\u52a9\u4e8e\u5b66\u4e60\uff1f<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1016\/j.cell.2019.08.040<\/div>\n<div><\/div>\n<div>\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7814\u7a76\u4eba\u5458\u7684\u4e00\u9879\u65b0\u7814\u7a76\u663e\u793a\uff0c\u7761\u7720\u5927\u8111\u4e2d\u4e0d\u540c\u7684\u7535\u6d3b\u52a8\u6a21\u5f0f\u53ef\u80fd\u4f1a\u5f71\u54cd\u6211\u4eec\u662f\u5426\u8bb0\u5f97\u524d\u4e00\u5929\u5b66\u5230\u7684\u4e1c\u897f\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u901a\u8fc7\u8c03\u8282\u5927\u9f20\u7761\u89c9\u65f6\u7684\u8111\u7535\u6ce2\uff0c\u53ef\u4ee5\u5f71\u54cd\u5176\u5b66\u4e60\u65b0\u6280\u80fd\u7684\u80fd\u529b\uff0c\u8fd9\u4e00\u7ed3\u679c\u5728\u589e\u5f3a\u4eba\u7c7b\u8bb0\u5fc6\u529b\u6216\u5fd8\u8bb0\u521b\u4f24\u7ecf\u5386\u65b9\u9762\u5177\u6709\u6f5c\u5728\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/div>\n<p><!--\/ewebeditor:page--><!--ewebeditor:page title=\"\"--><\/p>\n<div><\/div>\n<div>\u7814\u7a76\u4eba\u5458\u786e\u5b9a\u5728\u7761\u7720\u8fc7\u7a0b\u4e2d\u770b\u5230\u7684\u4e24\u79cd\u622a\u7136\u4e0d\u540c\u7684\u6162\u8111\u6ce2\uff0c\u5206\u522b\u79f0\u4e3a\u6162\u632f\u8361\u548c\u4e09\u89d2\u6ce2\uff0c\u5206\u522b\u589e\u5f3a\u6216\u51cf\u5f31\u4e86\u8fd1\u671f\u5b66\u4e60\u7684\u6280\u80fd\u6240\u6d89\u53ca\u7684\u7279\u5b9a\u8111\u7ec6\u80de\u7684\u6d3b\u52a8\u3002<\/div>\n<div><\/div>\n<div>\u301012\u3011\u5389\u5bb3\uff01\u540c\u4e00\u8bfe\u9898\u7ec4\u80cc\u9760\u80cc\u4e24\u7bc7Science\uff1a\u63ed\u793a\u7761\u7720\u548c\u7a81\u89e6\u8282\u5f8b\u4e4b\u95f4\u7684\u5173\u7cfb<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1126\/science.aav3617<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1126\/science.aav2642<\/div>\n<div><\/div>\n<div>\u5fb7\u56fd\u6155\u5c3c\u9ed1\u5927\u5b66\uff08LMU\uff09\u751f\u7269\u5b66\u5bb6\u5728\u300aScience\u300b\u6742\u5fd7\u7684\u4e24\u7bc7\u6587\u7ae0\u4e2d\u6307\u51fa\uff0c\u7761\u7720-\u89c9\u9192\u5468\u671f\u5bf9\u7a81\u89e6\u4e2d\u8c03\u8282\u5176\u6d3b\u52a8\u7684\u7684\u86cb\u767d\u8d28\u548c\u78f7\u9178\u5316\u52a8\u529b\u5b66\u81f3\u5173\u91cd\u8981\u3002<\/div>\n<div><\/div>\n<div>\u8fd9\u4e24\u7bc7\u6587\u7ae0\u63ed\u793a\u4e86\u7761\u7720\u548c\u6e05\u9192\u5468\u671f\uff08\u800c\u4e0d\u662f\u751f\u7269\u949f\uff09\u5982\u4f55\u9a71\u52a8\u5927\u8111\u4e2d\u86cb\u767d\u8d28\u4e30\u5ea6\u4ee5\u53ca\u7a81\u89e6\u86cb\u767d\u78f7\u9178\u5316\u8fc7\u7a0b\u7684\u5faa\u73af\u6765\u7ec4\u7ec7\u7a81\u89e6\u6d3b\u52a8\u3002&#8221;\u6211\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0c\u7761\u7720-\u89c9\u9192\u5468\u671f\u5728\u7a81\u89e6\u529f\u80fd\u7684\u8bb8\u591a\u65b9\u9762\u7684\u65f6\u95f4\u8c03\u63a7\u4e2d\u8d77\u7740\u6838\u5fc3\u4f5c\u7528\uff0c&#8221;Maria Robles\u8bf4\u3002<\/div>\n<div><\/div>\n<div>\u301013\u3011Science\uff1a \u65b0\u53d1\u73b0\uff01\u7761\u7720\u65f6\u6211\u4eec\u7684\u5927\u8111\u8bb0\u5fc6\u662f\u5982\u4f55\u50a8\u5b58\u7684\uff1f<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1126\/science.aay0616<\/div>\n<div><\/div>\n<div>\u6765\u81ea\u6cd5\u56fd\u7684\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u8868\u660e\uff0c\u6211\u4eec\u7761\u7720\u65f6\u5927\u8111\u4ea7\u751f\u7684\u4e09\u89d2\u6ce2\u5e76\u4e0d\u4f1a\u968f\u7740\u76ae\u8d28\u533a\u57df\u7684\u9759\u6b62\u800c\u53d8\u5f97\u6c89\u9ed8\uff0c\u76f8\u53cd\uff0c\u5b83\u4eec\u4f1a\u901a\u8fc7\u9694\u79bb\u4e00\u7c07\u7279\u6b8a\u7684\u795e\u7ecf\u5143\u800c\u6709\u52a9\u4e8e\u957f\u671f\u8bb0\u5fc6\u7684\u5f62\u6210\u3002<\/div>\n<div><\/div>\n<div>\u4f5c\u8005\u4ed4\u7ec6\u89c2\u5bdf\u4e86\u4e09\u89d2\u6ce2\u672c\u8eab\u7684\u7279\u5f81\u3002\u4ed6\u4eec\u53d1\u73b0\u5f53\u6240\u6709\u5176\u4ed6\u795e\u7ecf\u5143\u4fdd\u6301\u5b89\u9759\u65f6\uff0c\u6fc0\u6d3b\u7684\u5c11\u6570\u795e\u7ecf\u5143\u53ef\u4ee5\u6267\u884c\u91cd\u8981\u7684\u529f\u80fd\uff0c\u540c\u65f6\u907f\u514d\u53ef\u80fd\u7684\u5e72\u6270\u3002\u8fdb\u4e00\u6b65\uff0c\u4f5c\u8005\u63ed\u793a\u4e86\u6d77\u9a6c\u7684\u81ea\u53d1\u6fc0\u6d3b\u5982\u4f55\u51b3\u5b9a\u4e86\u5728\u4e09\u89d2\u6ce2\u671f\u95f4\u54ea\u4e9b\u76ae\u8d28\u795e\u7ecf\u5143\u4fdd\u6301\u6d3b\u8dc3\uff0c\u5e76\u63ed\u793a\u4e86\u4e24\u4e2a\u5927\u8111\u7ed3\u6784\u4e4b\u95f4\u7684\u4fe1\u606f\u4f20\u9012\u8fc7\u7a0b\u3002<\/div>\n<div><\/div>\n<div>\u301014\u3011Nat Neurosci\uff1a&#8221;\u591c\u95f4\u82b1\u56ed\u4e01&#8221;&#8211;\u514d\u75ab\u7ec6\u80de\u5728\u7761\u7720\u671f\u95f4\u4fee\u590d\u5927\u8111<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1038\/s41593-019-0514-0<\/div>\n<div><\/div>\n<div>\u4e4b\u524d\u7684\u5f88\u591a\u7814\u7a76\u8868\u660e\uff0c\u7761\u7720\u65f6\u5927\u8111\u4e2d\u4f1a\u53d1\u751f\u5f88\u591a&#8221;\u7f8e\u597d&#8221;\u7684\u4e8b\u60c5\uff1a\u4f8b\u5982\u5b66\u4e60\u548c\u8bb0\u5fc6\u5f97\u5230\u5de9\u56fa\uff0c\u4ee3\u8c22\u5e9f\u7269\u5f97\u4ee5\u6d88\u9664\u3002\u7136\u800c\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u9996\u6b21\u8868\u660e\uff0c\u5927\u8111\u4e2d\u88ab\u79f0\u4e3a&#8221;\u5c0f\u80f6\u8d28\u7ec6\u80de&#8221;\u7684\u514d\u75ab\u7ec6\u80de\u5728\u6211\u4eec\u7761\u7720\u65f6\u4e5f\u5341\u5206\u6d3b\u8dc3\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u5bf9\u5927\u8111\u53ef\u5851\u6027\uff0c\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u75f4\u5446\u75c7\u7b49\u75be\u75c5\u5177\u6709\u91cd\u8981\u7684\u5f71\u54cd\u3002<\/div>\n<div style=\"text-align: center\"><img decoding=\"async\" src=\"http:cache3.bioon.com\/webeditor\/uploadfile\/201912\/20191208212052403.jpg\" \/><\/div>\n<div style=\"text-align: center\">\u56fe\u7247\u6765\u6e90\uff1aMax Iglesias<\/div>\n<div><\/div>\n<div>\u301015\u3011eNeuro\uff1a\u7761\u7720\u65f6\u5e2e\u52a9\u8bb0\u5fc6\u4ea7\u751f\u7684\u8111\u56de\u8def<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1523\/ENEURO.0365-19.2019<\/div>\n<div><\/div>\n<div>\u963f\u5c14\u4f2f\u5854\u5927\u5b66\u7684\u795e\u7ecf\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u7684\u673a\u5236\uff0c\u53ef\u4ee5\u5e2e\u52a9\u4eba\u4eec\u5728\u6df1\u5ea6\u7761\u7720\u65f6\u5efa\u7acb\u8bb0\u5fc6\u3002\u8fd9\u9879\u7814\u7a76\u56f4\u7ed5&#8221;\u8fde\u5408\u6838&#8221;\u7684\u4f5c\u7528\u5c55\u5f00\uff0c\u8be5\u533a\u57df\u8fde\u63a5\u7740\u8d1f\u8d23\u4ea7\u751f\u8bb0\u5fc6\u7684\u5176\u4ed6\u4e24\u4e2a\u5927\u8111\u7ed3\u6784-&#8220;\u524d\u989d\u53f6\u76ae\u5c42\u548c\u6d77\u9a6c\u4f53&#8221;-\u5e76\u53ef\u80fd\u5728\u6162\u6ce2\u7761\u7720\u4e2d\u534f\u8c03\u5b83\u4eec\u7684\u6d3b\u52a8\u3002<\/div>\n<div><\/div>\n<div>\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u4f5c\u8005\uff0c\u535a\u58eb\u751fBrandon Hauer\u89e3\u91ca\u8bf4\uff1a&#8221;\u7761\u7720\u4e2d\u7684\u6162\u6ce2\u6709\u76ca\u4e8e\u6211\u4eec\u4e2a\u4eba\u7ecf\u5386\u76f8\u5173\u8bb0\u5fc6\u7684\u4ea7\u751f\uff0c\u8fd9\u5f88\u53ef\u80fd\u662f\u7531\u4e8e\u989d\u53f6\u524d\u989d\u53f6\u76ae\u5c42\u548c\u6d77\u9a6c\u4f53\u5185\u7684\u534f\u8c03\u6d3b\u52a8\u6240\u81f4\u3002\u6211\u4eec\u53d1\u73b0\u8fde\u5408\u6838\u8d1f\u8d23\u534f\u8c03\u8fd9\u4e24\u4e2a\u7ed3\u6784\u4e4b\u95f4\u7684\u540c\u6b65\u6162\u6ce2\u3002\u8fd9\u610f\u5473\u7740\u8be5\u7ed3\u6784\u53ef\u80fd\u5bf9\u4f9d\u8d56\u4e8e\u7761\u7720\u7684\u4e8b\u4ef6\u6574\u5408\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002&#8221;\u6162\u6ce2\u7761\u7720\u662f\u7761\u7720\u7684\u6700\u6df1\u9636\u6bb5\uff0c\u5728\u6b64\u671f\u95f4\uff0c\u5927\u8111\u4ee5\u975e\u5e38\u7f13\u6162\u7684\u9891\u7387\u632f\u8361\uff0c\u8fd9\u5bf9\u4e8e\u808c\u8089\u548c\u5927\u8111\u7684\u6062\u590d\u81f3\u5173\u91cd\u8981\u3002\u6b64\u5916\u7814\u7a76\u4e5f\u5df2\u7ecf\u8868\u660e\u5176\u5728\u8bb0\u5fc6\u5de9\u56fa\u4e2d\u7684\u4f5c\u7528\u3002<\/div>\n<div><\/div>\n<div>\u301016\u3011JGIM\uff1a\u745c\u4f3d\u7b49\u8fd0\u52a8\u53ef\u4ee5\u6cbb\u7597\u4e0b\u80cc\u90e8\u75bc\u75db\u5e76\u4fc3\u8fdb\u7761\u7720<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1007\/s11606-019-05329-4<\/div>\n<div><\/div>\n<div>\u6ce2\u58eb\u987f\u533b\u5b66\u4e2d\u5fc3\uff08BMC\uff09\u7684\u4e00\u9879\u65b0\u7814\u7a76\u663e\u793a\uff0c\u745c\u4f3d\u548c\u7269\u7406\u7597\u6cd5\uff08PT\uff09\u662f\u6cbb\u7597\u5e76\u53d1\u7684\u7761\u7720\u969c\u788d\u548c\u80cc\u90e8\u75bc\u75db\uff0c\u540c\u65f6\u51cf\u5c11\u7528\u836f\u9700\u6c42\u7684\u6709\u6548\u65b9\u6cd5\u3002<\/div>\n<div><\/div>\n<div>\u6587\u7ae0\u7ed3\u679c\u663e\u793a\uff1a\u745c\u4f3d\u8bfe\u621612\u5bf91 PT\u8bad\u7ec312\u5468\u540e\uff0c\u7761\u7720\u8d28\u91cf\u53ef\u6301\u7eed\u663e\u7740\u6539\u558452\u5468\uff0c\u8fd9\u8868\u660e\u8fd9\u4e9b\u975e\u836f\u7269\u65b9\u6cd5\u5177\u6709\u957f\u671f\u76ca\u5904\u3002\u6b64\u5916\uff0c\u5728\u6cbb\u75976\u5468\u540e\u65e9\u671f\u75bc\u75db\u5f97\u5230\u6539\u5584\u7684\u53c2\u4e0e\u8005\uff0c\u5728\u7ecf\u8fc7\u5b8c\u6574\u768412\u5468\u6cbb\u7597\u540e\uff0c\u5176\u7761\u7720\u6539\u5584\u7684\u53ef\u80fd\u6027\u589e\u52a0\u4e86\u4e09\u500d\u534a\uff0c\u8fd9\u8868\u660e\u75bc\u75db\u548c\u7761\u7720\u5bc6\u5207\u76f8\u5173\u3002<\/div>\n<div><\/div>\n<div>\u301017\u3011Cardiovasc Res\uff1a\u7761\u7720\u4e0d\u8db3\u5bfc\u81f4\u7a77\u4eba\u66f4\u5bb9\u6613\u5f97\u5fc3\u810f\u75c5<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1093\/cvr\/cvz267<\/div>\n<div><\/div>\n<div>\u6700\u8fd1\u53d1\u8868\u5728\u300aCardiovascular Research\u300b\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u7684\u53d1\u73b0\uff1a\u7761\u7720\u4e0d\u8db3\u662f\u5f31\u52bf\u7fa4\u4f53\u60a3\u5fc3\u810f\u75c5\u98ce\u9669\u66f4\u9ad8\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u8fd9\u662f\u7b2c\u4e00\u9879\u57fa\u4e8e\u4eba\u53e3\u7684\u5927\u578b\u7814\u7a76\uff0c\u65e8\u5728\u7814\u7a76\u7761\u7720\u4e0d\u8db3\u662f\u5426\u53ef\u4ee5\u90e8\u5206\u89e3\u91ca\u4e3a\u4ec0\u4e48\u7a77\u4eba\u60a3\u6709\u66f4\u591a\u7684\u5fc3\u810f\u75c5\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u7761\u7720\u8fc7\u5c11\u53ef\u4ee5\u89e3\u91ca\u7537\u6027\u7279\u5b9a\u804c\u4e1a\u7fa4\u4f53\u548c\u51a0\u5fc3\u75c5\u4e4b\u95f4\u7684\u8054\u7cfb\u3002<\/div>\n<div><\/div>\n<div>\u301018\u3011Nat Commun\uff1a\u7814\u7a76\u53d1\u73b0\u7761\u89c9\u7684\u7ec8\u6781\u610f\u4e49&#8211;\u4fee\u590d\u795e\u7ecf\u5143DNA\u635f\u4f24<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1038\/s41467-019-08806-w<\/div>\n<div><\/div>\n<div>\u6765\u81ea\u4ee5\u8272\u5217\u5df4\u4f0a\u5170\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u63ed\u5f00\u4e86\u7761\u7720\u80cc\u540e\u7684\u79d8\u5bc6\uff0c\u4ed6\u4eec\u53d1\u73b0\u7761\u89c9\u53ef\u4ee5\u589e\u52a0\u67d3\u8272\u4f53\u7684\u8fd0\u52a8\uff0c\u4ece\u800c\u51cf\u5c11\u795e\u7ecf\u5143\u4e2dDNA\u635f\u4f24\u7684\u5806\u79ef\u3002<\/div>\n<div><\/div>\n<div>\u901a\u8fc7\u5bf9\u7761\u7720\u3001\u67d3\u8272\u4f53\u52a8\u529b\u5b66\u3001\u795e\u7ecf\u5143\u6d3b\u52a8\u548cDNA\u53cc\u94fe\u65ad\u88c2\uff08DSBs\uff09\u7684\u64cd\u7eb5\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e0d\u7761\u89c9\u7684\u60c5\u51b5\u4e0b\u67d3\u8272\u4f53\u52a8\u529b\u5b66\u5f88\u4f4e\uff0cDSBs\u7684\u6570\u91cf\u4f1a\u589e\u52a0\u3002\u53cd\u8fc7\u6765\uff0c\u7761\u7720\u4f1a\u589e\u52a0\u67d3\u8272\u4f53\u7684\u52a8\u529b\u5b66\uff0c\u8fd9\u5bf9\u4e8e\u51cf\u5c11DSBs\u7684\u6570\u91cf\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\u67d3\u8272\u4f53\u52a8\u529b\u5b66\u662f\u9274\u5b9a\u5355\u4e2a\u7761\u7720\u7ec6\u80de\u7684\u6f5c\u5728\u6807\u8bb0\u7269\uff0c\u800c\u7761\u7720\u7684\u529f\u80fd\u5728\u4e8e\u7ef4\u6301\u7ec6\u80de\u6838\u4e2d\u67d3\u8272\u4f53\u7684\u7a33\u5b9a\u6027\u3002<\/div>\n<div><\/div>\n<div>\u301019\u3011JEM\uff1a\u7814\u7a76\u63ed\u793a\u7761\u7720\u4e3a\u4ec0\u4e48\u53ef\u4ee5\u589e\u5f3a\u514d\u75ab\u529b<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1084\/jem.20181169<\/div>\n<div><\/div>\n<div>\u6765\u81ea\u5fb7\u56fd\u7684\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u53d1\u73b0\u4e3a\u4ec0\u4e48\u6709\u65f6\u7761\u89c9\u662f\u6700\u597d\u7684\u836f\u3002\u6839\u636e\u6700\u65b0\u7814\u7a76\u6210\u679c\uff0c\u7761\u89c9\u63d0\u9ad8\u4e86\u4e00\u4e9b\u514d\u75ab\u7ec6\u80de\u7ed3\u5408\u5b83\u4eec\u7684\u9776\u6807\u7684\u80fd\u529b\u3002\u8fd9\u9879\u7814\u7a76\u5e2e\u52a9\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u7761\u89c9\u53ef\u4ee5\u5bf9\u6297\u611f\u67d3\uff0c\u800c\u5176\u4ed6\u60c5\u51b5\uff08\u6bd4\u5982\u6162\u6027\u538b\u529b\uff09\u4f1a\u4f7f\u8eab\u4f53\u66f4\u5bb9\u6613\u751f\u75c5\u3002<\/div>\n<p><!--\/ewebeditor:page--><!--ewebeditor:page title=\"\"--><\/p>\n<div><\/div>\n<div>Dimitrov\u53ca\u5176\u540c\u4e8b\u53d1\u73b0\u67d0\u4e9b\u6fc0\u52a8\u5242\uff08\u5305\u62ec\u80be\u4e0a\u817a\u7d20\u548c\u53bb\u7532\u80be\u4e0a\u817a\u7d20\uff0c\u4fc3\u708e\u5206\u5b50\u524d\u5217\u817a\u7d20E2\u548cD2\uff0c\u4ee5\u53ca\u795e\u7ecf\u8c03\u8282\u817a\u82f7\uff09\u4f1a\u5728T\u7ec6\u80de\u8bc6\u522b\u9776\u7ec6\u80de\u540e\u963b\u6b62T\u7ec6\u80de\u6fc0\u6d3b\u6574\u5408\u7d20\u3002&#8221;\u8bb8\u591a\u75c5\u7406\u6761\u4ef6\u4e0b\u90fd\u4f1a\u53d1\u73b0\u8fd9\u4e9b\u53ef\u4ee5\u6291\u5236\u6574\u5408\u7d20\u6fc0\u6d3b\u7684\u5206\u5b50\uff0c\u4f8b\u5982\u80bf\u7624\u751f\u957f\uff0c\u80ba\u7ed3\u6838\u611f\u67d3\u3001\u7f3a\u6c27\u3001\u538b\u529b\u7b49\u3002&#8221;Dimitrov\u8bf4\u9053\u3002&#8221;\u56e0\u6b64\u8fd9\u6761\u901a\u8def\u4e5f\u8bb8\u5bfc\u81f4\u4e86\u8fd9\u4e9b\u75be\u75c5\u76f8\u5173\u7684\u514d\u75ab\u6291\u5236\u3002&#8221;\u5f53\u673a\u4f53\u5904\u4e8e\u7761\u7720\u72b6\u6001\u4e0b\u80be\u4e0a\u817a\u7d20\u548c\u524d\u5217\u817a\u7d20\u4f1a\u4e0b\u8c03\u3002Dimitrov\u53ca\u5176\u540c\u4e8b\u6bd4\u8f83\u4e86\u5065\u5eb7\u5fd7\u613f\u8005\u5728\u7761\u7720\u6216\u8005\u71ac\u901a\u5bb5\u4e4b\u540e\u7684T\u7ec6\u80de\uff0c\u7ed3\u679c\u53d1\u73b0\u6b63\u5e38\u7761\u89c9\u540e\u7684T\u7ec6\u80de\u6574\u5408\u7d20\u6fc0\u6d3b\u7684\u6c34\u5e73\u663e\u7740\u9ad8\u4e8e\u71ac\u901a\u5bb5\u540e\u7684T\u7ec6\u80de\u7684\u6c34\u5e73\u3002\u968f\u540e\u7814\u7a76\u4eba\u5458\u786e\u5b9a\u4e86\u7761\u7720\u5bf9T\u7ec6\u80de\u6574\u5408\u7d20\u6fc0\u6d3b\u7684\u5f71\u54cd\u662f\u7531\u4e8eGas\u5076\u8054\u86cb\u767d\u53d7\u4f53\u6fc0\u6d3b\u6c34\u5e73\u964d\u4f4e\u3002<\/div>\n<div style=\"text-align: center\"><img decoding=\"async\" src=\"http:cache3.bioon.com\/webeditor\/uploadfile\/201912\/20191208212111193.png\" \/><\/div>\n<div style=\"text-align: center\">\u56fe\u7247\u6765\u6e90\uff1aScience<\/div>\n<div><\/div>\n<div>\u301020\u3011Current Bio\uff1a\u5468\u672b\u7761\u89c9\u5e76\u4e0d\u80fd\u7f13\u89e3\u75b2\u4e4f\u7684\u72b6\u6001<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1016\/j.cub.2019.01.069<\/div>\n<div><\/div>\n<div>\u5468\u672b\u7761\u89c9\u53ef\u4ee5\u4fee\u590d\u4e00\u6574\u71ac\u591c\u9020\u6210\u7684\u7761\u7720\u4e0d\u8db3\u7684\u5f71\u54cd\u5417\uff1f\u7814\u7a76\u8868\u660e\u60c5\u51b5\u5e76\u975e\u5982\u6b64\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8bd5\u56fe\u901a\u8fc7\u8865\u4e00\u89c9\u6765\u5f25\u8865\u524d\u51e0\u5929\u7684\u71ac\u591c\u4f1a\u8ba9\u4e8b\u60c5\u53d8\u5f97\u66f4\u7cdf\u3002<\/div>\n<div><\/div>\n<div>\u7814\u7a76\u4eba\u5458\u62db\u52df\u4e8636\u540d\u5e74\u9f84\u572818\u81f339\u5c81\u4e4b\u95f4\u7684\u5065\u5eb7\u6210\u5e74\u4eba\uff0c\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u505c\u7559\u4e86\u4e24\u5468\uff0c\u76d1\u6d4b\u4ed6\u4eec\u7684\u98df\u7269\u6444\u5165\u91cf\uff0c\u5149\u7167\u548c\u7761\u7720\u3002&nbsp; \u5728\u57fa\u7ebf\u6d4b\u8bd5\u540e\uff0c\u5c06\u5fd7\u613f\u8005\u5206\u6210\u5c0f\u7ec4\u3002\u4e00\u4e2a\u4eba\u6709\u8db3\u591f\u7684\u65f6\u95f4\u7761\u89c9 &#8211; \u6bcf\u665a9\u5c0f\u65f6\uff0c\u8fde\u7eed9\u665a\u3002\u5728\u540c\u4e00\u65f6\u671f\uff0c\u7b2c\u4e8c\u7ec4\u5141\u8bb8\u6bcf\u665a5\u5c0f\u65f6\u3002\u7b2c\u4e09\u5929\u665a\u4e0a\u7761\u89c9\u4e0d\u8d85\u8fc75\u5c0f\u65f6\uff0c\u8fde\u7eed5\u5929\uff0c\u7136\u540e\u662f\u4e00\u4e2a\u5468\u672b\uff0c\u4ed6\u4eec\u53ef\u4ee5\u5c3d\u53ef\u80fd\u591a\u5730\u7761\u89c9\uff0c\u7136\u540e\u518d\u56de\u52302\u5929\u7684\u9650\u5236\u6027\u7761\u7720\u3002\u7761\u7720\u53d7\u9650\u7ec4\u5728\u591c\u95f4\u5403\u5f97\u66f4\u591a\uff0c\u4f53\u91cd\u589e\u52a0\uff0c\u5e76\u4e14\u5728\u7814\u7a76\u671f\u95f4\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u4e0b\u964d\u3002\u867d\u7136\u5468\u672b\u6062\u590d\u7ec4\u7684\u4eba\u5728\u5468\u672b\u671f\u95f4\u770b\u5230\u4e86\u8f7b\u5fae\u7684\u6539\u5584\uff08\u5305\u62ec\u591c\u95f4\u96f6\u98df\u51cf\u5c11\uff09\uff0c\u4f46\u5f53\u7761\u7720\u53d7\u9650\u7684\u5de5\u4f5c\u5468\u6062\u590d\u65f6\uff0c\u8fd9\u4e9b\u597d\u5904\u6d88\u5931\u4e86\u3002<\/div>\n<div><\/div>\n<div>\u301021\u3011BMJ Nutrition\uff0c Prevention &amp; Health\uff1a\u665a\u9910\u4e0e\u7761\u89c9\u65f6\u95f4\u95f4\u9694\u591a\u4e45\u5408\u9002\uff1f<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1136\/bmjnph-2018-000011<\/div>\n<div><\/div>\n<div>\u6839\u636e\u4e00\u9879\u7814\u7a76\uff0c\u65e5\u672c\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u6bcf\u5929\u6700\u540e\u4e00\u9910\u548c\u5c31\u5bdd\u65f6\u95f4\u4e4b\u95f4\u5b58\u5728\u4e24\u5c0f\u65f6\u5dee\u8ddd\u5e76\u4e0d\u4f1a\u5f71\u54cd\u5065\u5eb7\u6210\u5e74\u4eba\u8840\u7cd6\u6c34\u5e73\u3002\u5728\u7761\u524d\u4e00\u6bb5\u65f6\u95f4\u5185\u4e0d\u8981\u5403\u996d\u6216\u96f6\u98df\u88ab\u8ba4\u4e3a\u5bf9\u957f\u671f\u5065\u5eb7\u662f\u6709\u76ca\u7684\u3002\u4f46\u662f\uff0c\u57fa\u4e8e\u8fd9\u4e00\u7814\u7a76\u7ed3\u679c\uff0c\u7814\u7a76\u4eba\u5458\u5efa\u8bae\u4eba\u4eec\u901a\u8fc7\u83b7\u5f97\u8db3\u591f\u7684\u7761\u7720\u4ee5\u53ca\u63a7\u5236\u4f53\u91cd\uff0c\u996e\u9152\u548c\u5438\u70df\u7684\u60c5\u51b5\uff0c\u80fd\u591f\u6709\u6548\u907f\u514d\u7cd6\u5c3f\u75c5\u548c\u5fc3\u810f\u75c5\u7684\u53d1\u751f\u3002<\/div>\n<div><\/div>\n<div>\u301022\u3011Science\u5b50\u520a\uff1a\u6311\u6218\u5e38\u89c4\uff01\u7761\u7720\u4e0d\u8db3\u5e76\u4e0d\u5f71\u54cd\u67d0\u4e9b\u52a8\u7269\u7684\u5bff\u547d<\/div>\n<div><\/div>\n<div>DOI\uff1a10.1126\/sciadv.aau9253.<\/div>\n<div><\/div>\n<div>\u6709\u4e9b\u679c\u8747\u6bcf\u5929\u4ec5\u7761\u51e0\u5206\u949f\u3002\u8ba9\u679c\u8747\u4fdd\u6301\u6e05\u9192\u5e76\u4e0d\u4f1a\u5bf9\u5bff\u547d\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\u3002\u50cf\u4efb\u4f55\u5176\u4ed6\u52a8\u7269\u4e00\u6837\uff0c\u679c\u8747\u4e5f\u7761\u89c9\u3002\u6839\u636e\u4e00\u9879\u65b0\u7684\u7814\u7a76\uff0c\u4e00\u4e9b\u679c\u8747\u4e2a\u4f53\u51e0\u4e4e\u4e0d\u4f11\u606f\u3002\u7761\u7720\u5265\u593a\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\u4e0e\u5176\u4ed6\u52a8\u7269\u5728\u4fdd\u6301\u6e05\u9192\u65f6\u89c2\u5bdf\u5230\u7684\u7834\u574f\u6027\u5f71\u54cd\u76f8\u6bd4\uff0c\u679c\u8747\u80fd\u5f88\u597d\u5730\u5e94\u5bf9\u3002<\/div>\n<div><\/div>\n<div>\u4e3a\u4e86\u89c2\u5bdf\u679c\u8747\u5728\u88ab\u8feb\u4fdd\u6301\u6e05\u9192\u65f6\u7684\u8868\u73b0\uff0c\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u64cd\u7eb5\u4e86\u4e00\u6839\u7ba1\u5b50\u4ee5\u81f3\u4e8e\u5f53\u679c\u8747\u843d\u4e0b\u65f6\u5b83\u4f1a\u65cb\u8f6c\uff0c\u4ece\u800c\u8ba9\u8fd9\u6839\u7ba1\u5b50\u7ffb\u8f6c\u8fc7\u6765\u5e76\u63a8\u52a8\u679c\u8747\u9192\u6765\u3002\u8fd9\u79cd\u60c5\u51b5\u4e00\u76f4\u6301\u7eed\u5230\u679c\u8747\u7684\u5bff\u547d\u7ed3\u675f\u4e3a\u6b62\u3002\u540c\u6837\uff0c\u4ee4\u4eba\u5403\u60ca\u7684\u7ed3\u679c\u662f\uff1a\u7761\u7720\u4e0d\u8db3\u7684\u96c4\u6027\u679c\u8747\u7684\u5b58\u6d3b\u65f6\u95f4\u4e0e\u7761\u7720\u672a\u53d7\u5e72\u6270\u7684\u96c4\u6027\u679c\u8747\u4e00\u6837\u957f\uff0c\u800c\u7761\u7720\u4e0d\u8db3\u7684\u96cc\u6027\u679c\u8747\u7684\u5b58\u6d3b\u65f6\u95f4\u8981\u6bd4\u7761\u7720\u672a\u53d7\u5e72\u6270\u7684\u96cc\u6027\u679c\u8747\uff08\u5b58\u6d3b\u65f6\u95f4\u4e3a41\u5929\uff09\u7565\u77ed\u4e00\u4e9b\uff1a\u5e73\u5747\u4e3a37.5\u5929\u3002<\/div>\n<div><\/div>\n<div>\u301023\u3011Nature\uff1a\u4e3a\u4ec0\u4e48\u4fdd\u8bc1\u5145\u8db3\u7761\u7720\u80fd\u591f\u964d\u4f4e\u5fc3\u8840\u7ba1\u75be\u75c5\u53d1\u751f\u98ce\u9669\uff1f<\/div>\n<div><\/div>\n<div>DOI\uff1a 10.1038\/s41586-019-0948-2<\/div>\n<div><\/div>\n<div>\u83b7\u5f97\u5145\u8db3\u7684\u7761\u7720\u662f\u5065\u5eb7\u7684\u5173\u952e\uff0c\u7814\u7a76\u8868\u660e\u7761\u7720\u4e0d\u8db3\u4f1a\u589e\u52a0\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u4e25\u91cd\u95ee\u9898\u7684\u98ce\u9669\u3002\u73b0\u5728\u9a6c\u8428\u8bf8\u585e\u5dde\u7efc\u5408\u533b\u9662\uff08MGH\uff09\u7684\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u53d1\u73b0\u4e86\u4e00\u79cd\u7761\u7720\u65b9\u5f0f\u53ef\u4ee5\u9632\u6b62\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7684\u5f62\u6210\u3002\u5728\u53d1\u8868\u4e8e\u300aNature\u300b\u6742\u5fd7\u4e0a\u7684\u8bba\u6587\u4e2d\uff0c\u4f5c\u8005\u63cf\u8ff0\u4e86\u7761\u7720\u4e0d\u8db3\u4f1a\u589e\u52a0\u708e\u75c7\u6027\u767d\u7ec6\u80de\u4ea7\u751f\u7684\u673a\u5236\uff0c\u8fd9\u4e9b\u767d\u7ec6\u80de\u5df2\u77e5\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/div>\n<div><\/div>\n<div>\u4e3a\u4e86\u7814\u7a76\u7761\u7720\u4e0d\u8db3\u4f1a\u589e\u52a0\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u7a0b\u5ea6\uff0cSwirski\u7684\u7814\u7a76\u5c0f\u7ec4\u5bf9\u9057\u4f20\u7f16\u7a0b\u7684\u5c0f\u9f20\u8fdb\u884c\u4e86\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4ee5\u53cd\u590d\u4e2d\u65ad\u7761\u7720\uff0c\u7c7b\u4f3c\u4e8e\u56e0\u566a\u97f3\u6216\u4e0d\u9002\u800c\u4e0d\u65ad\u9192\u6765\u7684\u7ecf\u5386\u3002\u867d\u7136\u7761\u7720\u5265\u593a\u5c0f\u9f20\u7684\u4f53\u91cd\uff0c\u80c6\u56fa\u9187\u6c34\u5e73\u6216\u8461\u8404\u7cd6\u8010\u91cf\u6ca1\u6709\u53d8\u5316\uff0c\u4f46\u4e0e\u540c\u4e00\u54c1\u79cd\u7684\u52a8\u7269\u76f8\u6bd4\uff0c\u7761\u7720\u6b63\u5e38\uff0c\u7761\u7720\u7834\u788e\u7684\u60a3\u8005\u4f1a\u51fa\u73b0\u66f4\u5927\u7684\u52a8\u8109\u6591\u5757\u5e76\u4e14\u5355\u6838\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6c34\u5e73\u66f4\u9ad8\u3002\u8fdb\u4e00\u6b65\u7684\u5b9e\u9a8c\u8868\u660e\uff0c\u7761\u7720\u5265\u593a\u7684\u5c0f\u9f20\u7684\u5e72\u7ec6\u80de\u9aa8\u9ad3\u4e2d\u7684\u4ea7\u91cf\u589e\u52a0\u4e86\u8fd1\u4e24\u500d\uff0c\u8fdb\u800c\u4ea7\u751f\u5927\u91cf\u767d\u7ec6\u80de\u3002\u4e00\u79cd\u53eb\u505ahypocretin\u7684\u6fc0\u7d20\uff08\u4e0b\u4e18\u8111\u4e2d\u4ea7\u751f\uff0c\u5df2\u77e5\u5728\u8c03\u8282\u7761\u7720\u4e2d\u53d1\u6325\u4f5c\u7528\uff09\uff0c\u88ab\u53d1\u73b0\u5728\u63a7\u5236\u767d\u7ec6\u80de\u751f\u6210\u4e2d\u53d1\u6325\u4e86\u610f\u60f3\u4e0d\u5230\u7684\u4f5c\u7528\u3002\u867d\u7136\u901a\u5e38\u5728\u52a8\u7269\uff08\u5305\u62ec\u4eba\u7c7b\uff09\u6e05\u9192\u65f6\u4fdd\u6301\u9ad8\u6c34\u5e73\u5730\u5206\u6ccc\uff0c\u4f46\u5728\u7761\u7720\u4e0d\u8db3\u7684\u5c0f\u9f20\u4e2d\uff0chypocretin\u6c34\u5e73\u663e\u7740\u964d\u4f4e\u3002<\/div>\n<div><\/div>\n<div>\u301024\u3011Science\uff1a\u91cd\u78c5\uff01\u65b0\u7814\u7a76\u53d1\u73b0\u4e00\u4e2a\u5728\u60a3\u75c5\u65f6\u4fc3\u8fdb\u7761\u7720\u7684\u57fa\u56e0<\/div>\n<div><\/div>\n<div>DOI\uff1a10.1126\/science.aat1650.<\/div>\n<div><\/div>\n<div>\u4eba\u7c7b\u5c06\u8fd1\u4e09\u5206\u4e4b\u4e00\u7684\u65f6\u95f4\u90fd\u5728\u7761\u7720\uff0c\u4f46\u662f\u7761\u7720\u4ecd\u7136\u662f\u751f\u7269\u5b66\u4e2d\u6700\u6301\u4e45\u5b58\u5728\u7684\u8c1c\u56e2\u4e4b\u4e00\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u79d1\u5b66\u5bb6\u4eec\u8fd8\u4e0d\u77e5\u9053\u662f\u4ec0\u4e48\u9057\u4f20\u6216\u5206\u5b50\u529b\u91cf\u4fc3\u4f7f\u4eba\u4eec\u9700\u8981\u7761\u7720\u3002\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u4f69\u96f7\u5c14\u66fc\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a7612000\u591a\u79cd\u679c\u8747\u54c1\u7cfb\uff0c\u53d1\u73b0\u4e86\u4e00\u4e2a\u79f0\u4f5cnemuri\u7684\u57fa\u56e0\u589e\u52a0\u4e86\u5bf9\u7761\u7720\u7684\u9700\u6c42\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728Science\u671f\u520a\u4e0a\u3002<\/div>\n<p><!--\/ewebeditor:page--><!--ewebeditor:page title=\"\"--><\/p>\n<div><\/div>\n<div>\u4e3a\u4e86\u5e94\u5bf9\u611f\u67d3\uff0cNEMURI\u4f3c\u4e4e\u53ef\u4ee5\u6740\u6b7b\u7ec6\u83cc\uff0c\u6700\u6709\u53ef\u80fd\u662f\u5728\u679c\u8747\u8eab\u4f53\u7684\u5916\u56f4\u90e8\u5206\u53d1\u751f\u7684\uff0c\u5e76\u901a\u8fc7\u5b83\u5728\u5927\u8111\u4e2d\u7684\u4f5c\u7528\u6765\u589e\u52a0\u7761\u7720\u3002\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u7c7b\u4f3cNEMURI\u8fd9\u6837\u7684\u591a\u79cd\u5206\u5b50\u5177\u6709\u591a\u79cd\u6709\u52a9\u4e8e\u62b5\u6297\u611f\u67d3\u7684\u529f\u80fd\uff0c\u4e0d\u8fc7\u5b83\u7684\u7761\u7720\u4fc3\u8fdb\u4f5c\u7528\u53ef\u80fd\u5bf9\u5bbf\u4e3b\u9632\u5fa1\u540c\u6837\u91cd\u8981\uff0c\u8fd9\u4e9b\u56e0\u4e3a\u5728\u60a3\u75c5\u671f\u95f4\uff0c\u7761\u7720\u589e\u52a0\u53ef\u4fc3\u8fdb\u679c\u8747\u7684\u5b58\u6d3b\u3002<\/div>\n<div style=\"text-align: center\"><img decoding=\"async\" src=\"http:cache3.bioon.com\/webeditor\/uploadfile\/201912\/20191208212133353.png\" \/><\/div>\n<div style=\"text-align: center\">\u56fe\u7247\u6765\u6e90\uff1aCC0 Public Domain<\/div>\n<div><\/div>\n<div>\u301025\u3011Science\uff1a\u7761\u7720\u5265\u593a\u52a0\u5feb\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e2d\u7684\u5927\u8111\u635f\u4f24<\/div>\n<div><\/div>\n<div>DOI\uff1a10.1126\/science.aav2546<\/div>\n<div><\/div>\n<div>\u7761\u7720\u4e0d\u4f73\u957f\u671f\u4ee5\u6765\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08Alzheimer&#8217;s 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