{"id":543,"date":"2020-09-23T00:14:01","date_gmt":"2020-09-22T16:14:01","guid":{"rendered":"http:\/\/unionmedin.com\/?p=543"},"modified":"2020-09-23T00:14:01","modified_gmt":"2020-09-22T16:14:01","slug":"%e4%b8%ad%e5%9b%bd%e7%a7%91%e5%ad%a6%e5%ae%b6%e5%9c%a8cns%e4%b8%8a%e5%8f%91%e8%a1%a8%e7%9a%84%e9%87%8d%e8%a6%81%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e8%a7%a3%e8%af%bb%ef%bc%81%ef%bc%882020%e5%b9%b45-3","status":"publish","type":"post","link":"https:\/\/unionmedin.com\/?p=543","title":{"rendered":"\u4e2d\u56fd\u79d1\u5b66\u5bb6\u5728CNS\u4e0a\u53d1\u8868\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\u89e3\u8bfb\uff01\uff082020\u5e745-7\u6708\uff09"},"content":{"rendered":"<p><!--ewebeditor:page title=\"\"--><P><STRONG>\u672c\u6587\u4e2d\uff0c\u5c0f\u7f16\u6574\u7406\u4e865-7\u6708\u4efd\u4e2d\u56fd\u79d1\u5b66\u5bb6\u4eec\u5728CNS\u4e09\u5927\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u7814\u7a76\u6210\u679c\uff0c\u4e0e\u5927\u5bb6\u4e00\u8d77\u5b66\u4e60\uff01<\/STRONG><\/P><P align=\"center\"><img decoding=\"async\" src=\"http:cache3.bioon.com\/webeditor\/uploadfile\/202007\/20200728000640637.jpg\" \/><\/P><P align=\"center\">\u56fe\u7247\u6765\u6e90\uff1aCC0 Public Domain<\/P><P>\u30101\u3011Cell\uff1a\u91cd\u78c5\uff01\u4e2d\u56fd\u79d1\u5b66\u5bb6\u6210\u529f\u7ed8\u5236\u51fa\u4eba\u7c7b\u80ba\u817a\u764c\u7684\u5168\u9762\u86cb\u767d\u8d28\u7ec4\u56fe\u8c31\uff01<\/P><P><STRONG>doi\uff1a10.1016\/j.cell.2020.05.043<\/STRONG><\/P><P>\u8fd1\u65e5\uff0c\u4e00\u7bc7\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Cell\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u4e2d\u79d1\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u7b49\u673a\u6784\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u5bf9103\u540d\u4e2d\u56fd\u80ba\u817a\u764c\uff08LUAD\uff0clung adenocarcinoma\uff09\u60a3\u8005\u8fdb\u884c\u4e86\u5168\u9762\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u5206\u6790\uff0c\u80ba\u817a\u764c\u662f\u5168\u7403\u6240\u6709\u764c\u75c7\u4e2d\u5f15\u53d1\u60a3\u8005\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/P><P>\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005\u63ed\u793a\u4e86\u4e0e\u80ba\u817a\u764c\u76f8\u5173\u7684\u5206\u5b50\u7279\u5f81\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u5206\u5b50\u7279\u5f81\u4e0e\u60a3\u8005\u4e34\u5e8a\u9884\u540e\u3001\u6f5c\u5728\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\u548c\u836f\u7269\u9776\u70b9\u4e4b\u95f4\u7684\u5173\u8054\uff1b\u5c3d\u7ba1\u8fd1\u4e9b\u5e74\u6765\u79d1\u5b66\u5bb6\u4eec\u5728\u80ba\u817a\u764c\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u5f88\u5927\u7684\u8fdb\u5c55\uff0c\u4f46\u5927\u91cf\u7684\u60a3\u8005\u4f9d\u7136\u7f3a\u5c11\u9776\u5411\u6027\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u7531\u4e8e\u86cb\u767d\u8d28\u662f\u751f\u7269\u6d3b\u6027\u7684\u201c\u76f4\u63a5\u6267\u884c\u8005\u201d\uff0c\u5bf9\u80ba\u817a\u764c\u8fdb\u884c\u5168\u9762\u86cb\u767d\u8d28\u7ec4\u5b66\u7814\u7a76\u6216\u8bb8\u5c31\u80fd\u586b\u8865\u57fa\u56e0\u7ec4\u5f02\u5e38\u548c\u81f4\u764c\u86cb\u767d\u8d28\u529f\u80fd\u4e4b\u95f4\u7684\u7a7a\u767d\u3002<\/P><P>\u30102\u3011Cell\uff1a\u4e2d\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u4e00\u79cdSARS-CoV-2\u706d\u6d3b\u75ab\u82d7\uff0cBBIBP-CorV\uff0c\u52a8\u7269\u5b9e\u9a8c\u663e\u793a\u6709\u6548\u7684\u4fdd\u62a4\u4f5c\u7528<\/P><P><STRONG>doi\uff1a10.1016\/j.cell.2020.06.008<\/STRONG><\/P><P>\u7531\u4e25\u91cd\u6025\u6027\u547c\u5438\u7cfb\u7edf\u7efc\u5408\u5f81(SARS-CoV-2)\u5f15\u8d77\u76842019\u51a0\u72b6\u75c5\u6bd2\u75c5(COVID-19)\u5927\u6d41\u884c\u5a01\u80c1\u7740\u5168\u7403\u516c\u5171\u536b\u751f\u3002\u4e3a\u9632\u63a7COVID-19\uff0c\u8feb\u5207\u9700\u8981\u7814\u5236\u75ab\u82d7\u3002\u63ed\u793a6\u67082\u65e5WHO\u516c\u5e03\u7684\u6570\u636e\uff0c\u76ee\u524d\u5168\u7403\u5df2\u7ecf\u670910\u79cd\u75ab\u82d7\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d1\u4e2a\u75ab\u82d7\u8fdb\u51653\u671f\u4e34\u5e8a\uff0c7\u4e2a\u75ab\u82d7\u8fdb\u51652\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/P><P>\u8fd1\u65e5\uff0c\u6765\u81ea\u5317\u4eac\u751f\u7269\u5236\u54c1\u7814\u7a76\u6240\u6709\u9650\u8d23\u4efb\u516c\u53f8\u3001\u4e2d\u56fd\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3\u3001\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u3001\u56fd\u5bb6\u98df\u54c1\u548c\u836f\u7269\u76d1\u7ba1\u5c40\u548c\u6e05\u534e\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5408\u4f5c\uff0c\u5728Cell\u6742\u5fd7\u4e0a\u53d1\u8868\u6700\u65b0\u7814\u7a76\u6210\u679c\uff0c\u4ecb\u7ecd\u4e86\u4ed6\u4eec\u5f00\u53d1\u7684\u4e00\u79cd\u65b0\u578b\u706d\u6d3b\u5019\u9009\u75ab\u82d7BBIBP-CorV\uff0c\u7814\u7a76\u7ed3\u679c\u663e\u793a\u8fd9\u79cd\u75ab\u82d7\u53ef\u4ee5\u8bf1\u53d1\u5f3a\u70c8\u7684\u9488\u5bf9SARS-CoV-2\u7684\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u62a5\u9053\u4e86\u4e00\u79cd\u706d\u6d3b\u7684SARS-CoV-2\u5019\u9009\u75ab\u82d7(BBIBP-CorV)\u7684\u5b9e\u9a8c\u6027\u751f\u4ea7\u3002\u5728\u52a8\u7269\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u8be5\u75ab\u82d7\u5728\u5c0f\u9f20\u3001\u5927\u9f20\u3001\u8c5a\u9f20\u3001\u5154\u5b50\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269(\u98df\u87f9\u7334\u548c\u6052\u6cb3\u7334)\u4f53\u5185\u8bf1\u5bfc\u9ad8\u6c34\u5e73\u7684\u4e2d\u548c\u6297\u4f53\u6ef4\u5ea6\uff0c\u4ee5\u63d0\u4f9b\u5bf9SARS-CoV-2\u7684\u4fdd\u62a4\u3002<\/P><P>\u30103\u3011Cell\u53ca\u5176\u5b50\u520a\u65b0\u7a81\u7834\uff1a\u4e2d\u56fd\u79d1\u5b66\u5bb6\u6210\u529f\u5f00\u53d1SARS-CoV-2\u5c0f\u9f20\u6a21\u578b<\/P><P><STRONG>doi\uff1a10.1016\/j.cell.2020.05.027 doi\uff1a10.1016\/j.chom.2020.05.020<\/STRONG><\/P><P>\u52a8\u7269\u6a21\u578b\u5bf9\u4e8e\u75c5\u6bd2\u7684\u75c5\u7406\u5b66\u3001\u75ab\u82d7\u5f00\u53d1\u548c\u836f\u7269\u7b5b\u67e5\u81f3\u5173\u91cd\u8981\u3002\u975e\u4eba\u7c7b\u7684\u7075\u957f\u7c7b\u52a8\u7269\u6a21\u578b\u662f\u4e34\u5e8a\u524d\u5b9e\u9a8c\u5e38\u7528\u7684\u52a8\u7269\u6a21\u578b\uff0c\u4f46\u662f\u8d39\u7528\u6602\u8d35\u3001\u4f7f\u7528\u4e0d\u4fbf\u3001\u9700\u8981\u7684\u8bbe\u65bd\u76f8\u5bf9\u590d\u6742\uff0c\u8fd9\u9650\u5236\u4e86\u8fd9\u79cd\u52a8\u7269\u6a21\u578b\u5728SARS-CoV-2\u4e2d\u7684\u5e94\u7528\u3002\u5c0f\u9f20\u6a21\u578b\u662f\u4e00\u79cd\u66f4\u7406\u60f3\u7684\u4e34\u5e8a\u524d\u5b9e\u9a8c\u6a21\u578b\uff0c\u56e0\u4e3a\u5176\u4ef7\u683c\u4fbf\u5b9c\u3001\u66f4\u5bb9\u6613\u83b7\u5f97\uff0c\u540c\u65f6\u9972\u517b\u6761\u4ef6\u7b80\u5355\u3002\u4f46\u662f\u5c0f\u9f20\u5e76\u4e0d\u8868\u8fbeSARS-CoV-2\u7528\u4e8e\u8fdb\u5165\u4eba\u4f53\u7ec6\u80de\u7684\u4eba\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u91762\uff08ACE2\uff09\u3002\u56e0\u6b64\u5f00\u53d1\u65b0\u7684\u9002\u7528\u4e8eSARS-CoV-2\u7814\u7a76\u7684\u5c0f\u9f20\u6a21\u578b\u6709\u52a9\u4e8e\u63a8\u52a8\u76f8\u5173\u75c5\u6bd2\u5b66\u7814\u7a76\u53ca\u6cbb\u7597\u9776\u70b9\u548c\u836f\u7269\u7684\u7814\u7a76\u548c\u5f00\u53d1\u3002<\/P><P>\u8fd1\u65e5\uff0c\u5728\u4e24\u9879\u5206\u522b\u53d1\u8868\u5728Cell\u548cCell Host &amp; Microbe\u4e0a\u7684\u7814\u7a76\u8bba\u6587\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u7684\u79d1\u5b66\u5bb6\u4eec\u5f00\u53d1\u4e86\u53ef\u4ee5\u7528\u4e8eSARS-CoV-2\u548cCOVID-19\u7814\u7a76\u7684\u5c0f\u9f20\u6a21\u578b\uff0c\u4e3aSARS-CoV-2\u53caCOVID-19\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b9\u4fbf\u5b9e\u7528\u800c\u7ecf\u6d4e\u5b9e\u60e0\u7684\u52a8\u7269\u6a21\u578b\u3002\u5728\u7b2c\u4e00\u9879\u53d1\u8868\u5728Cell\uff08Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2.\uff09\u4e0a\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e2d\u79d1\u9662\u6b66\u6c49\u75c5\u6bd2\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u5b66\u3001\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u548c\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u8868\u8fbe\u4eba\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u91762\uff08ACE2\uff09\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\uff08HFH4-hACE2 in C3B6 mice\uff09\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u8fd9\u79cd\u5c0f\u9f20\u611f\u67d3SARS-CoV-2\u540e\u7684\u80a0\u9053\u3001\u80ba\u708e\u75c7\u72b6\u53ca\u75c5\u7406\u5b66\u7279\u5f81\u4e0eCOVID-19\u60a3\u8005\u5f88\u76f8\u4f3c\u3002<\/P><P>\u30104\u3011\u4e24\u7bc7Nature\u91cd\u5927\u8fdb\u5c55\uff01\u4e2d\u56fd\u79d1\u5b66\u5bb6\u4ece\u75c5\u4eba\u4f53\u5185\u5206\u79bb\u51faSARS-CoV-2\u7279\u5f02\u6027\u7684\u4e2d\u548c\u6027\u6297\u4f53\uff01<\/P><P><STRONG>doi\uff1a10.1038\/s41586-020-2381-y doi\uff1a10.1038\/s41586-020-2380-z<\/STRONG><\/P><P>\u7531SARS-CoV-2\u5f15\u8d77\u76842019\u51a0\u72b6\u75c5\u6bd2\u75c5(COVID-19)\u5728\u5168\u7403\u66b4\u53d1\uff0c\u662f\u76ee\u524d\u7684\u5168\u7403\u536b\u751f\u7d27\u6025\u4e8b\u4ef6\uff0c\u6025\u9700\u6cbb\u7597\u6027\u836f\u7269\u4ee5\u53ca\u9884\u9632\u6027\u75ab\u82d7\u7f13\u89e3\u75ab\u60c5\u3002\u6297\u4f53\u662f\u6cbb\u7597COVID-19\u7684\u6709\u6548\u836f\u7269\u4e4b\u4e00\uff0c\u76ee\u524d\u5df2\u6709\u4e0d\u5c11\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u4f7f\u7528\u6062\u590d\u7684\u75c5\u4eba\u7684\u8840\u6e05\u8fdb\u884c\u6cbb\u7597\uff0c\u4f46\u662f\u8fd9\u79cd\u65b9\u6cd5\u96be\u4ee5\u6279\u91cf\u751f\u4ea7\uff0c\u540c\u65f6\u75c5\u4eba\u8840\u6e05\u4e2d\u7684\u6297\u4f53\u6570\u91cf\u7e41\u591a\uff0c\u7279\u5f02\u6027\u4e0d\u786e\u5b9a\uff0c\u56e0\u6b64\u6548\u679c\u5982\u4f55\u672a\u53ef\u77e5\u3002\u6240\u4ee5\u4ece\u8fd9\u4e9b\u5eb7\u590d\u7684\u75c5\u4eba\u4f53\u5185\u627e\u51faSARS-CoV-2\u7279\u5f02\u6027\u7684\u4e2d\u548c\u6027\u6297\u4f53\u5bf9\u4e8e\u4e0b\u4e00\u6b65\u7684\u6cbb\u7597\u6027\u6297\u4f53\u7684\u5f00\u53d1\u548c\u6279\u91cf\u751f\u4ea7\u81f3\u5173\u91cd\u8981\u30025\u670826\u65e5\uff0cNature\u6742\u5fd7\u540c\u65f6\u4e0a\u7ebf\u4e86\u4e24\u7bc7\u4e2d\u56fd\u79d1\u5b66\u5bb6\u5b8c\u6210\u7684\u6700\u65b0\u7814\u7a76\uff0c\u5206\u522b\u4ece\u75c5\u4eba\u4f53\u5185\u5206\u79bb\u51fa\u4e86SARS-CoV-2\u7279\u5f02\u6027\u7684\u9ad8\u6d3b\u6027\u4e2d\u548c\u6027\u6297\u4f53\u3002<\/P><!--\/ewebeditor:page--><!--ewebeditor:page title=\"\"--><P>\u5176\u4e2d\u4e00\u9879\u7814\u7a76\u9898\u4e3a&#8221;A human neutralizing antibody targets the receptor binding site of SARS-CoV-2&#8243;\uff0c\u7531\u4e2d\u56fd\u79d1\u5b66\u9662\u5fae\u751f\u7269\u7814\u7a76\u6240\u7684\u4e25\u666f\u534e\u56e2\u961f\u3001\u9ad8\u798f\u56e2\u961f\u3001\u738b\u5947\u6167\u56e2\u961f\u4e0e\u4e2d\u79d1\u9662\u6b66\u6c49\u75c5\u6bd2\u6240\u3001\u56fd\u5bb6\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc3\u75c5\u6bd2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5730\u575b\u533b\u9662\u7b49\u673a\u6784\u5408\u4f5c\u5b8c\u6210\u3002\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u62a5\u544a\u4e86\u4ece\u4e00\u540d\u6062\u590d\u671fCOVID-19\u60a3\u8005\u4e2d\u5206\u79bb\u51fa2\u79cd\u7279\u5f02\u6027\u4eba\u7c7b\u5355\u514b\u9686\u6297\u4f53(MAbs)\uff1aCA1\u548cCB6\u3002<\/P><P>\u30105\u3011Nature\uff1a\u4e2d\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u57fa\u4e8e\u534a\u7403\u5f62\u89c6\u7f51\u819c\u7684\u4eba\u9020\u773c<\/P><P><STRONG>doi\uff1a10.1038\/s41586-020-2285-x31<\/STRONG><\/P><P>\u636e\u62a5\u9053\uff0c\u4e00\u79cd\u4eba\u9020\u773c\u7403\u5c06\u5bc6\u96c6\u7684\u7eb3\u7c73\u7ea7\u5149\u4f20\u611f\u5668\u96c6\u6210\u5230\u4e00\u4e2a\u7c7b\u4f3c\u534a\u7403\u5f62\u89c6\u7f51\u819c\u7684\u7ec4\u4ef6\u4e2d\u3002\u5b83\u7684\u4e00\u4e9b\u611f\u5b98\u80fd\u529b\u53ef\u4e0e\u5b83\u7684\u751f\u7269\u5bf9\u624b\u76f8\u5ab2\u7f8e\u3002\u79d1\u5e7b\u5c0f\u8bf4\u4e2d\u7ecf\u5e38\u51fa\u73b0\u62e5\u6709\u4eba\u5de5\u773c\u775b\u7684\u673a\u5668\u4eba\uff0c\u4ee5\u53ca\u4e0e\u4eba\u7c7b\u5927\u8111\u76f8\u8fde\u63a5\u4ee5\u6062\u590d\u76f2\u4eba\u89c6\u529b\u7684\u4eff\u751f\u773c\u775b\u3002\u4eba\u4eec\u5df2\u7ecf\u82b1\u4e86\u5f88\u591a\u7cbe\u529b\u6765\u5f00\u53d1\u8fd9\u79cd\u8bbe\u5907\uff0c\u4f46\u5236\u9020\u7403\u5f62\u4eba\u7c7b\u773c\u775b&#8211;\u5c24\u5176\u662f\u534a\u7403\u5f62\u89c6\u7f51\u819c&#8211;\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\uff0c\u4e25\u91cd\u9650\u5236\u4e86\u4eba\u5de5\u548c\u4eff\u751f\u773c\u775b\u7684\u529f\u80fd\u3002\u8fd1\u65e5\u5728Nature\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u7684\u8303\u5fd7\u52c7\u56e2\u961f\u62a5\u9053\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u3001\u51f9\u6027\u7684\u534a\u7403\u5f62\u89c6\u7f51\u819c\uff0c\u5b83\u7531\u4e00\u7cfb\u5217\u7eb3\u7c73\u7ea7\u7684\u5149\u4f20\u611f\u5668(\u5149\u611f\u53d7\u5668)\u7ec4\u6210\uff0c\u6a21\u4eff\u4e86\u4eba\u7c7b\u89c6\u7f51\u819c\u4e2d\u7684\u5149\u611f\u53d7\u5668\u7ec6\u80de\u3002\u7814\u7a76\u4eba\u5458\u5c06\u8fd9\u79cd\u89c6\u7f51\u819c\u5e94\u7528\u4e8e\u7535\u5316\u5b66\u773c\u775b\uff0c\u8fd9\u79cd\u773c\u775b\u5177\u6709\u4e0e\u4eba\u773c\u76f8\u5f53\u7684\u591a\u79cd\u529f\u80fd\uff0c\u5e76\u4e14\u80fd\u591f\u5b8c\u6210\u83b7\u53d6\u56fe\u50cf\u6a21\u5f0f\u7684\u57fa\u672c\u529f\u80fd\u3002<\/P><P>\u4eba\u773c\u7684\u89c6\u7f51\u819c\u662f\u534a\u7403\u5f62\u7684\uff0c\u5b83\u7684\u5149\u5b66\u5e03\u5c40\u6bd4\u7167\u76f8\u673a\u4e2d\u7684\u5e73\u9762\u56fe\u50cf\u4f20\u611f\u5668\u66f4\u52a0\u7cbe\u5de7\uff1a\u89c6\u7f51\u819c\u7684\u7a79\u9876\u72b6\u81ea\u7136\u51cf\u5c11\u4e86\u901a\u8fc7\u6676\u72b6\u4f53\u7684\u5149\u7ebf\u4f20\u64ad\uff0c\u4ece\u800c\u4f7f\u7126\u70b9\u66f4\u52a0\u9510\u5229\u3002\u8303\u5fd7\u52c7\u56e2\u961f\u7684\u4eff\u751f\u7535\u5316\u5b66\u773c\u7684\u6838\u5fc3\u7ec4\u6210\u90e8\u5206\u662f\u4f5c\u4e3a\u89c6\u7f51\u819c\u7684\u9ad8\u5bc6\u5ea6\u5149\u654f\u5143\u4ef6\u9635\u5217\u3002\u5149\u654f\u5143\u4ef6\u76f4\u63a5\u5728\u6c27\u5316\u94dd\u534a\u7403\u5f62\u819c(Al2O3)\u7684\u5b54\u9699\u5185\u5f62\u6210\u3002<\/P><P align=\"center\"><img decoding=\"async\" src=\"http:cache3.bioon.com\/webeditor\/uploadfile\/202007\/20200728000704911.jpg\" \/><\/P><P align=\"center\">\u56fe\u7247\u6765\u6e90\uff1a<EM><STRONG>Cell<\/STRONG><\/EM>, 2020, doi:10.1016\/j.cell.2020.07.024<\/P><P>\u30106\u3011Cell\uff1a\u6211\u56fd\u5f00\u53d1\u51fa\u65b0\u578bmRNA\u65b0\u51a0\u80ba\u708e\u75ab\u82d7\uff0c\u53ef\u5728\u4f53\u5916\u4fdd\u6301\u70ed\u7a33\u5b9a\u6027\u81f3\u5c11\u4e00\u5468\u4ee5\u4e0a<\/P><P><STRONG>doi\uff1a10.1016\/j.cell.2020.07.024<\/STRONG><\/P><P>\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u519b\u4e8b\u533b\u5b66\u79d1\u5b66\u9662\u7b49\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u62a5\u9053\uff0c\u4e00\u79cd\u57fa\u4e8e\u4fe1\u4f7fRNA\uff08mRNA\uff09\u7684\u5b9e\u9a8c\u6027SARS-CoV-2\u75ab\u82d7\u80fd\u5728\u5c0f\u9f20\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u5f15\u8d77\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\u3002\u4e24\u6b21\u6ce8\u5c04\u8fd9\u79cd\u75ab\u82d7\u8db3\u4ee5\u4ea7\u751f\u5f3a\u5927\u7684\u514d\u75ab\u529b\uff0c\u5b8c\u5168\u9632\u6b62\u5c0f\u9f20\u611f\u67d3SARS-CoV-2\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e\u53d1\u8868\u5728Cell\u671f\u520a\u4e0a\u3002<\/P><P>\u79e6\u6210\u5cf0\u535a\u58eb\u8bf4\uff0c\u201c\u8fd9\u9879\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u5f3a\u52b2\u4fdd\u62a4\u4f5c\u7528\u548c\u8fd9\u79cd\u4fdd\u62a4\u4f5c\u7528\u7684\u660e\u786e\u514d\u75ab\u76f8\u5173\u6027\uff0c\u4e3a\u672a\u6765COVID-19\u75ab\u82d7\u5728\u4eba\u7c7b\u4e2d\u7684\u5f00\u53d1\u94fa\u5e73\u4e86\u524d\u8fdb\u7684\u9053\u8def\uff1b\u57fa\u4e8emRNA\u7684\u75ab\u82d7\u662f\u9884\u9632SARS-CoV-2\u611f\u67d3\u7684\u4e00\u79cd\u6709\u5438\u5f15\u529b\u7684\u9009\u62e9\uff0c\u8fd9\u662f\u56e0\u4e3a\u5b83\u4eec\u53ef\u4ee5\u5728\u51e0\u5468\u5185\u5feb\u901f\u8bbe\u8ba1\u548c\u5927\u89c4\u6a21\u751f\u4ea7\u3002\u6b64\u5916\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u5df2\u8bc1\u5b9e\u57fa\u4e8emRNA\u7684\u75ab\u82d7\u80fd\u591f\u8bf1\u5bfc\u51fa\u9488\u5bf9\u5404\u79cd\u75c5\u539f\u4f53\u7684\u5f3a\u6548\u548c\u5e7f\u6cdb\u7684\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u5e76\u4e14\u5177\u6709\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u3002<\/P><P>\u30107\u3011Cell\uff1a\u6211\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u51fa\u4e00\u79cd\u9488\u5bf9\u5305\u62ec\u65b0\u51a0\u75c5\u6bd2\u5728\u5185\u7684\u03b2\u51a0\u72b6\u75c5\u6bd2\u7684\u901a\u7528\u75ab\u82d7\u8bbe\u8ba1\u7b56\u7565<\/P><P><STRONG>doi\uff1a10.1016\/j.cell.2020.06.035<\/STRONG><\/P><P>\u51a0\u72b6\u75c5\u6bd2\uff08CoV\uff09\u662f\u4e00\u7ec4\u591a\u6837\u5316\u7684\u5305\u819c\u75c5\u6bd2\uff0c\u53ef\u8fdb\u4e00\u6b65\u7ec6\u5206\u4e3a\u56db\u4e2a\u5c5e\uff1a\u03b1-CoV\u3001\u03b2-CoV\u3001\u03b3-CoV\u548c\u03b4-CoV\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5df2\u77e5\u67097\u79cdCoV\u53ef\u5bfc\u81f4\u4eba\u7c7b\u75be\u75c5\u3002\u5176\u4e2d\uff0c\u4e24\u79cd\u03b1-CoV\uff08hCoV-NL63\u548chCoV-229E\uff09\u548c\u4e24\u79cd\u03b2-CoV\uff08HCoV-OC43\u548cHKU1\uff09\u4ec5\u5f15\u8d77\u81ea\u9650\u6027\u7684\u611f\u5192\u7c7b\u75be\u75c5\u3002\u7136\u800c\uff0c\u5176\u4f59\u4e09\u79cd\u03b2-CoV\uff08SARS-CoV\u3001MERS-CoV\u548cSARS-CoV-2\uff09\u5219\u4f1a\u5371\u53ca\u751f\u547d\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd8\u6ca1\u6709\u4e34\u5e8a\u4e0a\u6709\u6548\u7684\u9884\u9632\u6216\u6cbb\u7597\u4eba\u7c7b\u9ad8\u81f4\u75c5\u6027CoV\u611f\u67d3\u7684\u836f\u7269\uff0c\u8fd9\u51f8\u663e\u4e86\u75ab\u82d7\u5f00\u53d1\u7684\u8feb\u5207\u6027\u3002<\/P><P>\u5728CoV\u4e2d\uff0c\u5d4c\u5165\u5305\u819c\u4e2d\u7684\u523a\u7a81\u86cb\u767d\uff08S\uff09\u8d1f\u8d23\u8bc6\u522b\u5bbf\u4e3b\u7ec6\u80de\u53d7\u4f53\uff0c\u4ee5\u542f\u52a8\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u3002S\u86cb\u767d\u7684\u53d7\u4f53\u7ed3\u5408\u7ed3\u6784\u57df\uff08RBD\uff09\u662f\u8fd9\u79cd\u53d7\u4f53\u505c\u9760\u7684\u5fc5\u8981\u6761\u4ef6\u3002SARS-CoV\u548cSARS-CoV-2\u4f7f\u7528\u76f8\u540c\u7684\u529f\u80fd\u6027\u5bbf\u4e3b\u7ec6\u80de\u53d7\u4f53&#8212;\u4eba\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u5316\u91762\uff08hACE2\uff09\uff0c\u800cMERS-CoV\u4f7f\u7528\u4ebaCD26\uff08\u4e5f\u79f0\u4e3a\u4eba\u4e8c\u80bd\u80bd\u91764\uff0chDPP4\uff09\u3002\u79d1\u5b66\u5bb6\u4eec\u4e4b\u524d\u5df2\u63ed\u793a\u4e86\u8fd9\u4e9bCoV\u8bc6\u522b\u5bbf\u4e3b\u7ec6\u80de\u53d7\u4f53\u7684\u7ed3\u6784\u57fa\u7840\u3002<\/P><P>\u30108\u3011Science\uff1a\u4e2d\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\u4e24\u79cd\u975e\u7ade\u4e89\u6027\u4eba\u7c7b\u4e2d\u548c\u6297\u4f53\u53ef\u963b\u65adSARS-CoV-2\u75c5\u6bd2\u7ed3\u5408\u4ebaACE2\u53d7\u4f53<\/P><P><STRONG>doi\uff1a10.1126\/science.abc2241<\/STRONG><\/P><P>SARS-CoV-2\u75c5\u6bd2\u5c5e\u4e8e\u03b2\u51a0\u72b6\u75c5\u6bd2\u5c5e\uff0c\u03b2\u51a0\u72b6\u75c5\u6bd2\u5c5e\u5305\u62ec5\u79cd\u80fd\u591f\u611f\u67d3\u4eba\u7c7b\u7684\u75c5\u539f\u4f53\u3002\u5728\u8fd95\u79cd\u75c5\u539f\u4f53\u4e2d\uff0cSARS-CoV\u548c\u4e2d\u4e1c\u547c\u5438\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd2\uff08MERS-CoV\uff09\u662f\u4e24\u79cd\u9ad8\u81f4\u75c5\u6027\u51a0\u72b6\u75c5\u6bd2\u3002\u4e0e\u5176\u4ed6\u51a0\u72b6\u75c5\u6bd2\u4e00\u6837\uff0c\u4f4d\u4e8eSARS-CoV-2\u75c5\u6bd2\u8868\u9762\u4e0a\u7684\u523a\u7a81\u7cd6\u86cb\u767d\uff08S\u86cb\u767d\uff09\u540c\u6e90\u4e09\u805a\u4f53\u5728\u53d7\u4f53\u7ed3\u5408\u548c\u75c5\u6bd2\u8fdb\u5165\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002S\u86cb\u767d\u662f\u4e00\u79cdI\u7c7b\u878d\u5408\u86cb\u767d&#8212;\u6bcf\u4e2aS\u86cb\u767d\u539f\u4f53\u7531S1\u548cS2\u7ed3\u6784\u57df\u7ec4\u6210\uff0c\u53d7\u4f53\u7ed3\u5408\u7ed3\u6784\u57df\uff08RBD\uff09\u4f4d\u4e8eS1\u7ed3\u6784\u57df\u4e0a\u3002\u5148\u524d\u7684\u7814\u7a76\u663e\u793a\uff0c\u4e0eSARS-CoV\u7c7b\u4f3c\u7684\u662f\uff0cSARS-CoV-2\u4e5f\u5229\u7528\u4ebaACE2\uff08hACE2\uff09\u53d7\u4f53\u8fdb\u5165\u7ec6\u80de\u3002\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u53d1\u73b0\u4e86\u8bb8\u591a\u9776\u5411SARS-CoV\u6216MERS-CoV RBD\u7684\u4e2d\u548c\u6297\u4f53\u3002\u56e0\u6b64\uff0c\u7b5b\u9009\u51fa\u9776\u5411SARS-CoV-2 RBD\u7684\u4e2d\u548c\u6297\u4f53\u662f\u5f53\u52a1\u4e4b\u6025\u3002<\/P><!--\/ewebeditor:page--><!--ewebeditor:page title=\"\"--><P>\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u79d1\u5b66\u9662\u7b49\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u8868\u8fbe\u4e86SARS-CoV-2 RBD\u86cb\u767d\u4f5c\u4e3a\u8bf1\u9975\uff0c\u4eceCOVID-19\u60a3\u8005\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de\uff08PBMC\uff09\u4e2d\u5206\u79bb\u51fa\u7279\u5f02\u6027\u7684\u8bb0\u5fc6B\u7ec6\u80de\u3002\u7f16\u7801\u6297\u4f53\u91cd\u94fe\u548c\u8f7b\u94fe\u7684\u53ef\u53d8\u533a\u5206\u522b\u4ece\u4e0d\u540c\u7684B\u7ec6\u80de\u4e2d\u6269\u589e\u51fa\u6765\uff0c\u7136\u540e\u4e0e\u6297\u4f53\u6052\u5b9a\u533a\u4e00\u8d77\u88ab\u514b\u9686\u5230pCAGGS\u8d28\u7c92\u8f7d\u4f53\u4e2d\uff0c\u4ee5\u4ea7\u751fIgG1\u6297\u4f53\uff0c\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728Science\u671f\u520a\u4e0a\u3002<\/P><P>\u30109\u3011Cell\uff1a\u91cd\u5927\u8fdb\u5c55\uff01\u6211\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b014\u79cd\u53ef\u5f3a\u6548\u4e2d\u548cSARS-CoV-2\u7684\u4eba\u7c7b\u6297\u4f53<\/P><P><STRONG>doi\uff1a10.1016\/j.cell.2020.05.025<\/STRONG><\/P><P>\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u5317\u4eac\u5927\u5b66\u3001\u9996\u90fd\u533b\u79d1\u5927\u5b66\u3001\u519b\u4e8b\u533b\u5b66\u79d1\u5b66\u9662\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u548c\u5317\u4eac\u4e39\u5e8f\u836f\u4e1a\u6709\u9650\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u6d4b\u5e8f\uff0c\u6210\u529f\u5730\u4ece\u6062\u590d\u671f\u8840\u6d46\u4e2d\u9274\u5b9a\u51fa\u591a\u79cd\u9488\u5bf9\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2SARS-CoV-2&#8212;\u5bfc\u81f4\u547c\u5438\u9053\u75be\u75c5COVID-19\u7684\u81f4\u75c5\u75c5\u6bd2&#8212;\u7684\u9ad8\u5f3a\u6548\u4e2d\u548c\u6297\u4f53\u3002\u7531\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u4ea7\u751f\u7684\u4e2d\u548c\u6297\u4f53\u53ef\u4ee5\u6709\u6548\u9632\u6b62\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u3002\u6765\u81ea\u52a8\u7269\u7814\u7a76\u7684\u65b0\u7ed3\u679c\u663e\u793a\uff0c\u4ed6\u4eec\u53d1\u73b0\u7684\u8fd9\u4e9b\u4e2d\u548c\u6297\u4f53\u4e3aCOVID-19\u63d0\u4f9b\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4ee5\u53ca\u77ed\u671f\u9884\u9632\u624b\u6bb5\u3002\u8fd9\u6807\u5fd7\u7740\u62b5\u6297COVID-19\u75ab\u60c5\u7684\u4e00\u4e2a\u91cd\u8981\u91cc\u7a0b\u7891\u3002<\/P><P>\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e\u53d1\u8868\u5728Cell\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cPotent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients&#8217; B 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